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Pcdh17 Gene Detail
Summary
  • Symbol
    Pcdh17
  • Name
    protocadherin 17
  • Synonyms
    C030033F14Rik, LOC219228
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684924
    NCBI Gene: 219228
  • Gene Overview
    MyGene.info: PCDH17
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:84443563-84537565 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 43.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    790 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684924
protein coding gene Chr14:84443563-84539002 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021606
protein coding gene Chr14:79824865-79932388 (+)
A/J MGP_AJ_G0021564
protein coding gene Chr14:77724894-77820977 (+)
AKR/J MGP_AKRJ_G0021540
protein coding gene Chr14:80055815-80149304 (+)
BALB/cJ MGP_BALBcJ_G0021570
protein coding gene Chr14:77708029-77801321 (+)
C3H/HeJ MGP_C3HHeJ_G0021348
protein coding gene Chr14:79769785-79867040 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022010
protein coding gene Chr14:83199541-83300420 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019549
protein coding gene Chr14:75653910-75745837 (+)
CAST/EiJ MGP_CASTEiJ_G0020865
protein coding gene Chr14:76801141-76906404 (+)
CBA/J MGP_CBAJ_G0021316
protein coding gene Chr14:86025207-86117819 (+)
DBA/2J MGP_DBA2J_G0021440
protein coding gene Chr14:77116176-77211743 (+)
FVB/NJ MGP_FVBNJ_G0021416
protein coding gene Chr14:76465254-76561314 (+)
LP/J MGP_LPJ_G0021508
protein coding gene Chr14:80867851-80968619 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021444
protein coding gene Chr14:85512362-85632942 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022033
protein coding gene Chr14:79323470-79423152 (+)
PWK/PhJ MGP_PWKPhJ_G0020608
protein coding gene Chr14:73985229-74075593 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020445
protein coding gene Chr14:75365528-75460425 (+)
WSB/EiJ MGP_WSBEiJ_G0020918
protein coding gene Chr14:79818244-79918043 (+)



Homology
more
  • Human Ortholog
    PCDH17, protocadherin 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PCDH17, protocadherin 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCDH68, PCH68
  • Links
    NCBI Gene ID: 27253
    neXtProt AC: NX_O14917
    UniProt: O14917

  • Chr Location
    13q21.1; chr13:57630104-57728931 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8700
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PCDH17
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired synaptic transmission, increased synaptic vesicle number and decreased depression-related behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 219228 NCBI Gene Model | MGI Sequence Detail 94003 C57BL/6J ±  kb
transcript NM_001013753 RefSeq | MGI Sequence Detail 9509 C57BL/6  
polypeptide NP_001013775 RefSeq | MGI Sequence Detail 1157 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1924636
References
more
  • Summaries
    All 38
    Developmental Gene Expression 9
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:62200 Yagi T, et al., Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 2000 May 15;14(10):1169-80
  • Latest
    J:238731 Harrington AJ, et al., MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife. 2016 Oct 25;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory