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Tppp2 Gene Detail
Summary
  • Symbol
    Tppp2
  • Name
    tubulin polymerization-promoting protein family member 2
  • Synonyms
    LOC219038, LOC386487
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684923
    NCBI Gene: 219038
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:51918430-51920704 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 26.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684923
protein coding gene Chr14:51918425-51920704 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021284
protein coding gene Chr14:45940817-45943714 (+)
A/J MGP_AJ_G0021241
protein coding gene Chr14:44746177-44748437 (+)
AKR/J MGP_AKRJ_G0021217
protein coding gene Chr14:46362473-46364791 (+)
BALB/cJ MGP_BALBcJ_G0021245
protein coding gene Chr14:44854082-44856342 (+)
C3H/HeJ MGP_C3HHeJ_G0021025
protein coding gene Chr14:46168359-46170641 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021684
protein coding gene Chr14:47953144-47958592 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019229
protein coding gene Chr14:43937107-43939305 (+)
CAST/EiJ MGP_CASTEiJ_G0020544
protein coding gene Chr14:43132108-43134379 (+)
CBA/J MGP_CBAJ_G0020992
protein coding gene Chr14:49423939-49426490 (+)
DBA/2J MGP_DBA2J_G0021113
protein coding gene Chr14:44511072-44513527 (+)
FVB/NJ MGP_FVBNJ_G0021096
protein coding gene Chr14:44093216-44095506 (+)
LP/J MGP_LPJ_G0021188
protein coding gene Chr14:46541412-46544261 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021119
protein coding gene Chr14:48866254-48869823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021711
protein coding gene Chr14:45749966-45752176 (+)
PWK/PhJ MGP_PWKPhJ_G0020293
protein coding gene Chr14:41257522-41259870 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020120
protein coding gene Chr14:41775148-41777425 (+)
WSB/EiJ MGP_WSBEiJ_G0020597
protein coding gene Chr14:46050061-46052006 (+)



Homology
more
  • Human Ortholog
    TPPP2, tubulin polymerization promoting protein family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TPPP2, tubulin polymerization promoting protein family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C14orf8, CT152, P18, p25beta
  • Links
    NCBI Gene ID: 122664
    neXtProt AC: NX_P59282
    UniProt: P59282

  • Chr Location
    14q11.2; chr14:21024262-21036352 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit oligoasthenozoospermia with irregular mitochondria and reduced ATP content in sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 219038 NCBI Gene Model | MGI Sequence Detail 2275 C57BL/6J ±  kb
transcript NM_001128634 RefSeq | MGI Sequence Detail 747 Not Specified  
polypeptide Q0P5Y3 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 2
Other
Accession IDs
less
MGI:2686636
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:141707 Yalcin S, et al., Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008 Sep 12;283(37):25692-705
  • Latest
    J:279929 Zhu F, et al., Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. J Cell Mol Med. 2019 Apr;23(4):2583-2594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory