Tppp2 MGI Mouse Gene Detail - MGI:2684923 - tubulin polymerization-promoting protein family member 2

Symbol

Tppp2
Name

tubulin polymerization-promoting protein family member 2
Synonyms

LOC219038, LOC386487

Feature Type

protein coding gene
IDs

MGI:2684923
NCBI Gene: 219038
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:52155887-52158161 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.72 cM
Mapping Data

1 experiment

SNPs within 2kb

47 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684923	protein coding gene	Chr14:52155882-52158161 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021284	protein coding gene	Chr14:45940817-45943714 (+)
A/J	MGP_AJ_G0021241	protein coding gene	Chr14:44746177-44748437 (+)
AKR/J	MGP_AKRJ_G0021217	protein coding gene	Chr14:46362473-46364791 (+)
BALB/cJ	MGP_BALBcJ_G0021245	protein coding gene	Chr14:44854082-44856342 (+)
C3H/HeJ	MGP_C3HHeJ_G0021025	protein coding gene	Chr14:46168359-46170641 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021684	protein coding gene	Chr14:47953144-47958592 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019229	protein coding gene	Chr14:43937107-43939305 (+)
CAST/EiJ	MGP_CASTEiJ_G0020544	protein coding gene	Chr14:43132108-43134379 (+)
CBA/J	MGP_CBAJ_G0020992	protein coding gene	Chr14:49423939-49426490 (+)
DBA/2J	MGP_DBA2J_G0021113	protein coding gene	Chr14:44511072-44513527 (+)
FVB/NJ	MGP_FVBNJ_G0021096	protein coding gene	Chr14:44093216-44095506 (+)
LP/J	MGP_LPJ_G0021188	protein coding gene	Chr14:46541412-46544261 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021119	protein coding gene	Chr14:48866254-48869823 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021711	protein coding gene	Chr14:45749966-45752176 (+)
PWK/PhJ	MGP_PWKPhJ_G0020293	protein coding gene	Chr14:41257522-41259870 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020120	protein coding gene	Chr14:41775148-41777425 (+)
WSB/EiJ	MGP_WSBEiJ_G0020597	protein coding gene	Chr14:46050061-46052006 (+)

Human Ortholog

TPPP2, tubulin polymerization promoting protein family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPPP2, tubulin polymerization promoting protein family member 2
Synonyms

C14orf8, CT152, P18, p25beta
Links

HGNC:19293

NCBI Gene ID: 122664

neXtProt AC: NX_P59282

UniProt: P59282
Chr Location

14q11.2; chr14:21024109-21036352 (+) GRCh38

MGI Vertebrate Homology

Tppp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPPP2
Gene Tree

Tppp2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
4 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

2
Genomic Mutations

1 involving Tppp2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit oligoasthenozoospermia with irregular mitochondria and reduced ATP content in sperm.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase foxo3

ZFIN tppp2

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All Sequences

32
RefSeq

5
UniProt

1
CCDS

CCDS49487.1

Ensembl

ENSMUSG00000008813 (Evidence)
NCBI Gene

219038

			Length	Strain/Species	Flank
genomic	219038	NCBI Gene Model \| MGI Sequence Detail	2275	C57BL/6J	± kb
transcript	NM_001128634	RefSeq \| MGI Sequence Detail	747	Not Specified
polypeptide	Q0P5Y3	UniProt \| EBI \| MGI Sequence Detail	170	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030847 tubulin polymerization-promoting protein family member 2

(term hierarchy)
InterPro Domains

IPR011992 EF-hand domain pair

IPR008907 Tubulin polymerization-promoting protein

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All nucleic 6

cDNA 6

Microarray probesets 2

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MGI:2686636

Summaries

All 26

Gene Ontology 5

Phenotypes 4
Earliest

J:141707 Yalcin S, et al., Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. J Biol Chem. 2008 Sep 12;283(37):25692-705
Latest

J:279929 Zhu F, et al., Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice. J Cell Mol Med. 2019 Apr;23(4):2583-2594

TSS for Tppp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125435	Chr14:52155875-52155887 (+)	-6 bp
Tssr125436	Chr14:52155909-52155917 (+)	26 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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