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Vcpkmt Gene Detail
Summary
  • Symbol
    Vcpkmt
  • Name
    valosin containing protein lysine (K) methyltransferase
  • Synonyms
    Gm71, LOC207965, Mettl21d
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684917
    NCBI Gene: 207965
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:69577628-69583110 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 28.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684917
protein coding gene Chr12:69576730-69583110 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019797
protein coding gene Chr12:69278323-69283723 (-)
A/J MGP_AJ_G0019755
protein coding gene Chr12:66688376-66696208 (-)
AKR/J MGP_AKRJ_G0019731
protein coding gene Chr12:68689143-68694803 (-)
BALB/cJ MGP_BALBcJ_G0019735
protein coding gene Chr12:67145758-67152434 (-)
C3H/HeJ MGP_C3HHeJ_G0019541
protein coding gene Chr12:69151772-69158064 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020187
protein coding gene Chr12:71495626-71501026 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017807
protein coding gene Chr12:64232922-64238315 (-)
CAST/EiJ MGP_CASTEiJ_G0019092
protein coding gene Chr12:63905200-63912815 (-)
CBA/J MGP_CBAJ_G0019510
protein coding gene Chr12:74120499-74126223 (-)
DBA/2J MGP_DBA2J_G0019626
protein coding gene Chr12:66604050-66609474 (-)
FVB/NJ MGP_FVBNJ_G0019613
protein coding gene Chr12:65499891-65505867 (-)
LP/J MGP_LPJ_G0019698
protein coding gene Chr12:69221333-69226946 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019652
protein coding gene Chr12:77450206-77455630 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020222
protein coding gene Chr12:68158006-68163406 (-)
PWK/PhJ MGP_PWKPhJ_G0018857
protein coding gene Chr12:60871868-60880914 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018652
protein coding gene Chr12:62543482-62549757 (-)
WSB/EiJ MGP_WSBEiJ_G0019143
protein coding gene Chr12:68794350-68800925 (-)



Homology
more
  • Human Ortholog
    VCPKMT, valosin containing protein lysine methyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VCPKMT, valosin containing protein lysine methyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C14orf138, METTL21D, VCP-KMT
  • Links
    NCBI Gene ID: 79609
    neXtProt AC: NX_Q9H867
    UniProt: Q9H867

  • Chr Location
    14q21.3; chr14:50100456-50118343 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56995
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VCPKMT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit no abnormal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000049882 Ensembl Gene Model | MGI Sequence Detail 5483 C57BL/6J ±  kb
transcript ENSMUST00000058639 Ensembl | MGI Sequence Detail 1109 Not Applicable  
polypeptide ENSMUSP00000055002 Ensembl | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory