Ttc6 Gene Detail

Summary

• Symbol
  Ttc6
• Name
  tetratricopeptide repeat domain 6
• Synonyms
  4921506M07Rik, AU024163, EG639426, Gm9813, LOC217602

• Feature Type
  protein coding gene
• IDs
  MGI:2684915
  NCBI Gene: 70846
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr12:57564113-57737928 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 24.70 cM
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  732 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684915	protein coding gene	Chr12:57546704-57737928 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019762	protein coding gene	Chr12:56740559-56940765 (+)
A/J	MGP_AJ_G0019721	protein coding gene	Chr12:54670773-54849847 (+)
AKR/J	MGP_AKRJ_G0019696	protein coding gene	Chr12:56404927-56577438 (+)
BALB/cJ	MGP_BALBcJ_G0019701	protein coding gene	Chr12:55041598-55214175 (+)
C3H/HeJ	MGP_C3HHeJ_G0019506	protein coding gene	Chr12:56491324-56677079 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020153	protein coding gene	Chr12:58433215-58608830 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017773	protein coding gene	Chr12:53124993-53294315 (+)
CAST/EiJ	MGP_CASTEiJ_G0019058	protein coding gene	Chr12:51418957-51591751 (+)
CBA/J	MGP_CBAJ_G0019475	protein coding gene	Chr12:60516356-60712319 (+)
DBA/2J	MGP_DBA2J_G0019591	protein coding gene	Chr12:54587176-54751974 (+)
FVB/NJ	MGP_FVBNJ_G0019579	protein coding gene	Chr12:53870306-54042696 (+)
LP/J	MGP_LPJ_G0019663	protein coding gene	Chr12:56720649-56899029 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019617	protein coding gene	Chr12:62058574-62284031 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020187	protein coding gene	Chr12:55855392-56036961 (+)
PWK/PhJ	MGP_PWKPhJ_G0018825	protein coding gene	Chr12:48981513-49159879 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018618	protein coding gene	Chr12:50289370-50465425 (+)
WSB/EiJ	MGP_WSBEiJ_G0019109	protein coding gene	Chr12:56394485-56579467 (+)

Homology

• Human Ortholog
  TTC6, tetratricopeptide repeat domain 6

• Vertebrate Orthologs
  3

• Human Ortholog
  TTC6, tetratricopeptide repeat domain 6
  Orthology source: HGNC
• Synonyms
  C14orf25, NCRNA00291
• Links
  HGNC:19739

  NCBI Gene ID: 319089

  UniProt: Q86TZ1

  
  
• Chr Location
  14q21.1; chr14:37595199-37842628 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 78002
  1 mouse;1 rat;1 chimpanzee
  
• HCOP
  human homology predictions: TTC6
• Gene Tree
  Ttc6
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Targeted
  2
• Genomic Mutations
  1 involving Ttc6
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  0 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• Assay Results
  16
• Tissues
  14
• cDNA Data
  11
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase ttc6

Interactions

• Ttc6 interacts with 102 markers (Mir7-1, Mir27a, Mir27b, ...) View All

Sequences &
Gene Models

• All Sequences
  72
• RefSeq
  33
• UniProt
  3
• CCDS
  CCDS25927.1, CCDS83963.1
• UniGene
  449996, 422588, 84118

• Ensembl
  ENSMUSG00000046782 (Evidence)
• NCBI Gene
  70846

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000046782	Ensembl Gene Model | MGI Sequence Detail	173816	C57BL/6J
transcript	ENSMUST00000172939	Ensembl | MGI Sequence Detail	5782	Not Applicable
polypeptide	ENSMUSP00000134273	Ensembl | MGI Sequence Detail	1857	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• InterPro Domains
  IPR006597 Sel1-like repeat
  IPR011990 Tetratricopeptide-like helical domain superfamily
  IPR019734 Tetratricopeptide repeat
  IPR001440 Tetratricopeptide repeat 1
  IPR013026 Tetratricopeptide repeat-containing domain

Molecular
Reagents

• All nucleic 11

  cDNA 11

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1918096, MGI:3034924, MGI:3645573

References

• Summaries
  All 25

  Developmental Gene Expression 2

  Phenotypes 4
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Ttc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113528	Chr12:57564097-57564105 (+)	-12 bp
Tssr113529	Chr12:57564111-57564150 (+)	18 bp
Tssr113530	Chr12:57576140-57576166 (+)	12,040 bp