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Maneal Gene Detail
Summary
  • Symbol
    Maneal
  • Name
    mannosidase, endo-alpha-like
  • Synonyms
    LOC215090
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684896
    NCBI Gene: 215090
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124749032-124755964 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684896
 protein coding gene Chr4:124749032-124774731 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028757
 protein coding gene Chr4:126414554-126421478 (-)
A/J MGP_AJ_G0028716
 protein coding gene Chr4:121456601-121463533 (-)
AKR/J MGP_AKRJ_G0028669
 protein coding gene Chr4:124769560-124776692 (-)
BALB/cJ MGP_BALBcJ_G0028739
 protein coding gene Chr4:122030438-122037362 (-)
C3H/HeJ MGP_C3HHeJ_G0028453
 protein coding gene Chr4:124865550-124872474 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029181
 protein coding gene Chr4:131277673-131284605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026454
 protein coding gene Chr4:114627696-114634723 (-)
CAST/EiJ MGP_CASTEiJ_G0027886
 protein coding gene Chr4:122925324-122932263 (-)
CBA/J MGP_CBAJ_G0028419
 protein coding gene Chr4:134533014-134539938 (-)
DBA/2J MGP_DBA2J_G0028568
 protein coding gene Chr4:121928065-121934989 (-)
FVB/NJ MGP_FVBNJ_G0028535
 protein coding gene Chr4:120554186-120561117 (-)
LP/J MGP_LPJ_G0028669
 protein coding gene Chr4:126708577-126715501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028561
 protein coding gene Chr4:139533088-139540019 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029219
 protein coding gene Chr4:125138435-125145359 (-)
PWK/PhJ MGP_PWKPhJ_G0027607
 protein coding gene Chr4:118349407-118356821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027433
 protein coding gene Chr4:120910224-120917163 (-)
WSB/EiJ MGP_WSBEiJ_G0027966
 protein coding gene Chr4:125212066-125219003 (-)



Homology
more
  • Human Ortholog
    MANEAL, mannosidase endo-alpha like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MANEAL, mannosidase endo-alpha like
  • Links
    NCBI Gene ID: 149175
    neXtProt AC: NX_Q5VSG8
    UniProt: Q5VSG8

  • Chr Location
    1p34.3; chr1:37793847-37801137 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Maneal
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    19 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042763 Ensembl Gene Model | MGI Sequence Detail 6933 C57BL/6J ±  kb
transcript ENSMUST00000064444 Ensembl | MGI Sequence Detail 2727 Not Applicable  
polypeptide ENSMUSP00000066000 Ensembl | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory