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Trim38 Gene Detail
Summary
  • Symbol
    Trim38
  • Name
    tripartite motif-containing 38
  • Synonyms
    LOC214158
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684869
    NCBI Gene: 214158
  • Gene Overview
    MyGene.info: TRIM38
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr13:23778500-23791731 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 9.92 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684869
protein coding gene Chr13:23769913-23791731 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020368
protein coding gene Chr13:21228912-21237801 (+)
A/J MGP_AJ_G0020317
protein coding gene Chr13:20836620-20845509 (+)
AKR/J MGP_AKRJ_G0020297
protein coding gene Chr13:21088939-21097828 (+)
BALB/cJ MGP_BALBcJ_G0020315
protein coding gene Chr13:20832983-20841872 (+)
C3H/HeJ MGP_C3HHeJ_G0020119
protein coding gene Chr13:21161782-21170671 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020752
protein coding gene Chr13:22008514-22017437 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018340
protein coding gene Chr13:19613105-19623201 (+)
CAST/EiJ MGP_CASTEiJ_G0019636
protein coding gene Chr13:20845850-20854815 (+)
CBA/J MGP_CBAJ_G0020073
protein coding gene Chr13:22865005-22873894 (+)
DBA/2J MGP_DBA2J_G0020199
protein coding gene Chr13:20364685-20373574 (+)
FVB/NJ MGP_FVBNJ_G0020183
protein coding gene Chr13:20015449-20024338 (+)
LP/J MGP_LPJ_G0020272
protein coding gene Chr13:21536712-21545677 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020210
protein coding gene Chr13:23157982-23166947 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020794
protein coding gene Chr13:20942631-20951520 (+)
PWK/PhJ MGP_PWKPhJ_G0019390
protein coding gene Chr13:20396213-20405157 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019207
protein coding gene Chr13:19748552-19757470 (+)
WSB/EiJ MGP_WSBEiJ_G0019696
protein coding gene Chr13:21082988-21091912 (+)



Homology
more
  • Human Ortholog
    TRIM38, tripartite motif containing 38
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TRIM38, tripartite motif containing 38
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF15, RORET
  • Links
    NCBI Gene ID: 10475
    neXtProt AC: NX_O00635
    UniProt: O00635

  • Chr Location
    6p22.2; chr6:25962689-25988867 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased poly(I:C) and LPS-induced IFN-beta, TNFalpha and IL6 with increased induced mortality induced by poly(I:C), LPS or S. typhimurium infection,
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 214158 NCBI Gene Model | MGI Sequence Detail 13232 C57BL/6J ±  kb
transcript NM_001029935 RefSeq | MGI Sequence Detail 1480 C57BL/6  
polypeptide NP_001025106 RefSeq | MGI Sequence Detail 471 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 1
References
more
  • Summaries
    All 28
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:241587 Hu MM, et al., Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med. 2017 Apr 03;214(4):973-989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory