Nlrp1a
Gene Detail

Symbol Name ID

Nlrp1a NLR family, pyrin domain containing 1A MGI:2684861

Synonyms

Nalp1, Nalp1a

Feature Type

protein coding gene

Genetic Map

Chromosome 11

43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:71092236-71144704 bp, - strand From VEGA annotation of GRCm38   52469 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:19080  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: NALP protein
Gene Tree: Nlrp1a

Human homologs

Human Homolog		NLRP1, NLR family, pyrin domain containing 1
NCBI Gene ID		22861
neXtProt AC		NX_Q9C000
Human Synonyms		CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1
Human Chr (Location)		17p13.2; chr17:5404719-5487832 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NLRP1

Alleles and phenotypes

All alleles(3) : Targeted(2) Chemically induced(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	cell death, defense response to bacterium, ...
Component	NLRP1 inflammasome complex, nucleus
Function	ATP binding, enzyme binding, ...

External Resources: FuncBase

Expression

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(2) cDNA(2)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000006088 (Evidence)
Ensembl Gene Model	ENSMUSG00000069830 (Evidence)
Entrez Gene	195046 (Evidence)
UniGene	240227
DFCI	TC1627841
DoTS	DT.101228121, DT.91427803
NIA Mouse Gene Index	U378586
Consensus CDS Project	CCDS48838.1
International Mouse Knockout Project Status	Nlrp1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006088	VEGA Gene Model | MGI Sequence Detail	52469	C57BL/6J
transcript	OTTMUST00000049360	VEGA | MGI Sequence Detail	3903	Not Applicable
polypeptide	OTTMUSP00000022851	VEGA | MGI Sequence Detail	1300	Not Applicable

All sequences(32) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(425 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	Death-like domain
InterPro	IPR025307	FIIND domain
InterPro	IPR007111	NACHT nucleoside triphosphatase

References

(Earliest) J:85109 Stehlik C, et al., CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. J Biol Chem. 2003 Aug 22;278(34):31941-9
(Latest) J:191055 Masters SL, et al., NLRP1 Inflammasome Activation Induces Pyroptosis of Hematopoietic Progenitor Cells. Immunity. 2012 Dec 14;37(6):1009-23
All references(27)

Other accession IDs

MGI:2684860