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Nlrp1a
Gene Detail
Symbol

Name
ID
Nlrp1a
NLR family, pyrin domain containing 1A
MGI:2684861
Synonyms
Nalp1, Nalp1a
Feature Type
protein coding gene
Genetic Map
Chromosome 11
43.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:71092236-71144704 bp, - strand
From VEGA annotation of GRCm38

  52469 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133820  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: NLRP1
Protein SuperFamily: NALP protein
Gene Tree: Nlrp1a

Human
homologs
NLRP1, NLR family, pyrin domain containing 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 22861
neXtProt AC: NX_Q9C000

Human Synonyms: CARD7, CIDED, CLR17.1, DEFCAP, DEFCAP-L/S, NAC, NALP1, PP1044, SLEV1, VAMAS1

Human Chr (Location): 17p13.2; chr17:5501399-5584512 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human NLRP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Chemically induced (ENU)(1) Targeted(4)
Genomic Mutations involving Nlrp1a (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for an ENU-induced allele develop a multi-organ neutrophilic inflammatory disease. Homozygotes for the same ENU-induced allele develop a similar but lethal condition and exhibit neutrophilia, lymphopenia, splenomegaly, loss of peritoneal macrophages, and premature death.
 
Interactions
Nlrp1a interacts with 7 markers (Mir143, Mir381, Mir664, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000006088 (Evidence)
Ensembl Gene Model ENSMUSG00000069830 (Evidence)
Entrez Gene 195046 (Evidence)
UniGene 240227
DFCI TC1627841
DoTS DT.101228121, DT.91427803
NIA Mouse Gene Index U378586
Consensus CDS Project CCDS48838.1
International Mouse Phenotyping Consortium Status Nlrp1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006088 VEGA Gene Model | MGI Sequence Detail 52469 C57BL/6J ±  kb
transcript OTTMUST00000049360 VEGA | MGI Sequence Detail 3903 Not Applicable 
polypeptide OTTMUSP00000022851 VEGA | MGI Sequence Detail 1300 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(529 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR025307 FIIND domain
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
References
(Earliest) J:85109 Stehlik C, et al., CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways. J Biol Chem. 2003 Aug 22;278(34):31941-9
(Latest) J:210638 Gerlic M, et al., NLRP1a expression in Srebp-1a-deficient mice. Cell Metab. 2014 Mar 4;19(3):345-6
All references(27)
Other
accession IDs
MGI:2684860

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory