Tmprss11a
Gene Detail

Symbol Name ID

Tmprss11a transmembrane protease, serine 11a MGI:2684853

Synonyms

LOC194597

Feature Type

protein coding gene

Genetic Map

Chromosome 5

43.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:86410410-86468990 bp, - strand From VEGA annotation of GRCm38   58581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Tmprss11a ± 2 cM)

Protein SuperFamily: transmembrane serine protease, TMPRSS11A type
Gene Tree: Tmprss11a

Human ortholog

TMPRSS11A transmembrane protease, serine 11A NCBI Gene ID 339967
Human Synonyms: ECRG1
Human Chr4:68776019-68829232 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous mice for a targeted mutation appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	cell cycle, proteolysis
Component	extracellular region, integral to membrane, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (35)    Tissues (35)    Images (1)
Theiler Stages: 28

Assay Type	Results
RT-PCR	35

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(3) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000035104 (Evidence)
Ensembl Gene Model	ENSMUSG00000072845 (Evidence)
Entrez Gene	194597 (Evidence)
DFCI	TC1583470
DoTS	DT.40175820
NIA Mouse Gene Index	U026348
EC	3.4.21.-
Consensus CDS Project	CCDS51531.1
International Mouse Knockout Project Status	Tmprss11a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035104	VEGA Gene Model | MGI Sequence Detail	58581	C57BL/6J
transcript	OTTMUST00000089304	VEGA | MGI Sequence Detail	2657	Not Applicable
polypeptide	OTTMUSP00000048793	VEGA | MGI Sequence Detail	389	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(328 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR017329	Peptidase S1A, HAT/DESC1
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR000082	SEA
Protein Ontology	PR:000016448	transmembrane protease serine 11A

References

(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:175364 Sales KU, et al., Expression and Genetic Loss of Function Analysis of the HAT/DESC Cluster Proteases TMPRSS11A and HAT. PLoS One. 2011;6(8):e23261
All references(28)