Lrsam1
Gene Detail

Symbol Name ID

Lrsam1 leucine rich repeat and sterile alpha motif containing 1 MGI:2684789

Synonyms

MGC:56830

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:32925220-32961614 bp, - strand From VEGA annotation of GRCm38   36395 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:44526  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lrsam1

Human homologs

Human Homolog		LRSAM1, leucine rich repeat and sterile alpha motif containing 1
NCBI Gene ID		90678
neXtProt AC		NX_Q6UWE0
Human Synonyms		CMT2P, RIFLE, TAL
Human Chr (Location)		9q33.3; chr9:130213765-130265780 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LRSAM1

Alleles and phenotypes

All alleles(23) : Targeted(3) Gene trapped(20)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	negative regulation of endocytosis, non-lytic virus budding, ...
Component	cytoplasm, membrane part
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (47)    Tissues (8)    Images (19)
Theiler Stages: 23

Assay Type	Results
RNA in situ	47

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) cDNA(43)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000012573 (Evidence)
Ensembl Gene Model	ENSMUSG00000026792 (Evidence)
Entrez Gene	227738 (Evidence)
UniGene	248037
DFCI	TC1581667
DoTS	DT.101377631
NIA Mouse Gene Index	U022513
EC	6.3.2.-
Consensus CDS Project	CCDS15935.1
International Mouse Knockout Project Status	Lrsam1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012573	VEGA Gene Model | MGI Sequence Detail	36395	C57BL/6J
transcript	OTTMUST00000029945	VEGA | MGI Sequence Detail	4030	Not Applicable
polypeptide	OTTMUSP00000013464	VEGA | MGI Sequence Detail	727	Not Applicable

All sequences(49) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(143 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR025875	Leucine rich repeat 4
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000009950	E3 ubiquitin-protein ligase LRSAM1

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)