Lzts1
Gene Detail

Symbol Name ID

Lzts1 leucine zipper, putative tumor suppressor 1 MGI:2684762

Synonyms

F37, FEZ1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:69135503-69140953 bp, - strand From NCBI annotation of GRCm38   5451 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lzts1

Human homologs

Human Homolog		LZTS1, leucine zipper, putative tumor suppressor 1
NCBI Gene ID		11178
neXtProt AC		NX_Q9Y250
Human Synonyms		F37, FEZ1
Human Chr (Location)		8p22; chr8:20103676-20112803 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LZTS1

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Targeted heterozygous or homozygous inactivation of this gene results in increased incidence of both spontaneous and carcinogen-induced tumors. Homozygous null MEFs show accelerated mitotic progression, resistance to taxol- and nocodazole-induced M phase arrest, and impaired chromosome segregation.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell cycle, negative regulation of macroautophagy, ...
Component	apical plasma membrane, cell body, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (57)    Tissues (7)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	57

cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(8)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000036306 (Evidence)
Entrez Gene	211134 (Evidence)
UniGene	479807
DFCI	TC1603635
DoTS	DT.102554187
NIA Mouse Gene Index	U029896
Consensus CDS Project	CCDS22345.1
International Mouse Knockout Project Status	Lzts1

Sequences

Length	Strain/Species
genomic	211134	NCBI Gene Model | MGI Sequence Detail	5451	C57BL/6J
transcript	NM_199364	RefSeq | MGI Sequence Detail	1800	Not Specified
polypeptide	P60853	UniProt | EBI | MGI Sequence Detail	599	Not Applicable

All sequences(17) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009638	Fez1
Protein Ontology	PR:000031112	leucine zipper putative tumor suppressor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:87418 Ishii H, et al., The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33
(Latest) J:183879 Kropp M, et al., The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development. Dev Dyn. 2012 May;241(5):984-94
All references(27)