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Lzts1
Gene Detail
Symbol

Name
ID
Lzts1
leucine zipper, putative tumor suppressor 1
MGI:2684762
Synonyms
F37, FEZ1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:69132669-69184225 bp, - strand
From VEGA annotation of GRCm38

  51557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: LZTS1
Gene Tree: Lzts1

Human
homologs
LZTS1, leucine zipper, putative tumor suppressor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11178
neXtProt AC: NX_Q9Y250

Human Synonyms: F37, FEZ1

Human Chr (Location): 8p22; chr8:20246165-20303981 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LZTS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted heterozygous or homozygous inactivation of this gene results in increased incidence of both spontaneous and carcinogen-induced tumors. Homozygous null MEFs show accelerated mitotic progression, resistance to taxol- and nocodazole-induced M phase arrest, and impaired chromosome segregation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, negative regulation of macroautophagy, ...
Component apical plasma membrane, cell body, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (57)    Tissues (7)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LZTS1 ; Xenbase lzts1    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000044658 (Evidence)
Ensembl Gene Model ENSMUSG00000036306 (Evidence)
Entrez Gene 211134 (Evidence)
UniGene 479807
DFCI TC1603635
DoTS DT.102554187
NIA Mouse Gene Index U029896
Consensus CDS Project CCDS22345.1
International Mouse Phenotyping Consortium Status Lzts1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044658 VEGA Gene Model | MGI Sequence Detail 51557 C57BL/6J ±  kb
transcript OTTMUST00000117477 VEGA | MGI Sequence Detail 5019 Not Applicable 
polypeptide OTTMUSP00000065693 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(567 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031112 leucine zipper putative tumor suppressor 1
References
(Earliest) J:87418 Ishii H, et al., The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33
(Latest) J:183879 Kropp M, et al., The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development. Dev Dyn. 2012 May;241(5):984-94
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory