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Lzts1
Gene Detail
 Symbol
Name
ID
Lzts1
leucine zipper, putative tumor suppressor 1
MGI:2684762
Synonyms F37, FEZ1
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:69132669-69184225 bp, - strand
From VEGA annotation of GRCm38

  51557 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lzts1

Human
homologs
Human Homolog LZTS1, leucine zipper, putative tumor suppressor 1
NCBI Gene ID 11178
neXtProt AC  NX_Q9Y250
Human Synonyms  F37, FEZ1
Human Chr (Location)  8p22; chr8:20246165-20303981 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LZTS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Targeted heterozygous or homozygous inactivation of this gene results in increased incidence of both spontaneous and carcinogen-induced tumors. Homozygous null MEFs show accelerated mitotic progression, resistance to taxol- and nocodazole-induced M phase arrest, and impaired chromosome segregation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, negative regulation of macroautophagy, ...
Component apical plasma membrane, cell body, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (57)    Tissues (7)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 57
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(8)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000044658 (Evidence)
Ensembl Gene ModelENSMUSG00000036306 (Evidence)
Entrez Gene211134 (Evidence)
UniGene479807
DFCITC1603635
DoTSDT.102554187
NIA Mouse Gene IndexU029896
Consensus CDS ProjectCCDS22345.1
International Mouse Knockout Project StatusLzts1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044658 VEGA Gene Model | MGI Sequence Detail 51557 C57BL/6J ±  kb
transcript OTTMUST00000117477 VEGA | MGI Sequence Detail 5019 Not Applicable 
polypeptide OTTMUSP00000065693 VEGA | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(567 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000031112 leucine zipper putative tumor suppressor 1
References (Earliest) J:87418 Ishii H, et al., The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3928-33
(Latest) J:183879 Kropp M, et al., The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development. Dev Dyn. 2012 May;241(5):984-94
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory