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Unc79 Gene Detail
Summary
  • Symbol
    Unc79
  • Name
    unc-79 homolog
  • Synonyms
    9030205A07Rik, Mlca3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684729
    NCBI Gene: 217843
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:102948859-103184065 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1383 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684729
protein coding gene Chr12:102948328-103184228 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020043
protein coding gene Chr12:104605911-104860316 (+)
A/J MGP_AJ_G0019999
protein coding gene Chr12:100586008-100823441 (+)
AKR/J MGP_AKRJ_G0019975
protein coding gene Chr12:103425114-103666014 (+)
BALB/cJ MGP_BALBcJ_G0019985
protein coding gene Chr12:100941085-101179072 (+)
C3H/HeJ MGP_C3HHeJ_G0019787
protein coding gene Chr12:103906652-104157863 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020434
protein coding gene Chr12:107859787-108113526 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018047
protein coding gene Chr12:97627273-97863370 (+)
CAST/EiJ MGP_CASTEiJ_G0019333
protein coding gene Chr12:98755679-99012114 (+)
CBA/J MGP_CBAJ_G0019759
protein coding gene Chr12:111861769-112133733 (+)
DBA/2J MGP_DBA2J_G0019870
protein coding gene Chr12:100150676-100344155 (+)
FVB/NJ MGP_FVBNJ_G0019859
protein coding gene Chr12:98884551-99079984 (+)
LP/J MGP_LPJ_G0019946
protein coding gene Chr12:104498792-104703444 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019899
protein coding gene Chr12:115324982-115588637 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020463
protein coding gene Chr12:102959330-103204196 (+)
PWK/PhJ MGP_PWKPhJ_G0019096
protein coding gene Chr12:94664288-94905697 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018892
protein coding gene Chr12:97200077-97403755 (+)
WSB/EiJ MGP_WSBEiJ_G0019387
protein coding gene Chr12:103891070-104093464 (+)



Homology
more
  • Human Ortholog
    UNC79, unc-79 homolog, NALCN channel complex subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UNC79, unc-79 homolog, NALCN channel complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA1409
  • Links
    NCBI Gene ID: 57578
    neXtProt AC: NX_Q9P2D8
    UniProt: Q9P2D8

  • Chr Location
    14q32.12; chr14:93333219-93710473 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation results in lethality within the first week after birth, mostly at P0 or P1. Pups fail to nurse and have no milk in stomachs resulting in weakness, inactivity and no weight gain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021198 Ensembl Gene Model | MGI Sequence Detail 235207 C57BL/6J ±  kb
transcript ENSMUST00000179002 Ensembl | MGI Sequence Detail 7965 Not Applicable  
polypeptide ENSMUSP00000136332 Ensembl | MGI Sequence Detail 2654 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 3
Other
Accession IDs
less
MGI:3701678
References
more
  • Summaries
    All 27
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:111319 Nakayama M, et al., A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 2006 Aug;20(10):1718-20
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory