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Arap2 Gene Detail
Summary
  • Symbol
    Arap2
  • Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Synonyms
    Centd1, mKIAA0580
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684416
    NCBI Gene: 212285
  • Gene Overview
    MyGene.info: ARAP2
Location & Maps
more
  • Sequence Map
    Chr5:62602445-62766159 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163715 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 32.04 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARAP2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CENTD1, PARX
  • Links
    NCBI Gene ID: 116984
    neXtProt AC: NX_Q8WZ64

  • Chr Location
    4p14; chr4:36065998-36244357 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 9064
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ARAP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotype references
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    4 involving Arap2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034699 VEGA Gene Model | MGI Sequence Detail 163715 C57BL/6J ±  kb
transcript OTTMUST00000088114 VEGA | MGI Sequence Detail 7306 Not Applicable  
polypeptide OTTMUSP00000048010 VEGA | MGI Sequence Detail 1703 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    591 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000004194 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
  • InterPro Domains
    IPR001164 Arf GTPase activating protein
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR000159 Ras-associating (RA) domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
Molecular
Reagents
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  • All nucleic 45
    cDNA 45

    Microarray probesets 4
Other
Accession IDs
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MGI:2684994
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory