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Vwa2 Gene Detail
Summary
  • Symbol
    Vwa2
  • Name
    von Willebrand factor A domain containing 2
  • Synonyms
    Amaco
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684334
    NCBI Gene: 240675
  • Gene Overview
    MyGene.info: VWA2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56874416-56912078 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 52.02 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684334
protein coding gene Chr19:56874249-56912078 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025270
protein coding gene Chr19:57254883-57293971 (+)
A/J MGP_AJ_G0025246
protein coding gene Chr19:54425027-54462538 (+)
AKR/J MGP_AKRJ_G0025215
protein coding gene Chr19:56145281-56182956 (+)
BALB/cJ MGP_BALBcJ_G0025241
protein coding gene Chr19:54501517-54539125 (+)
C3H/HeJ MGP_C3HHeJ_G0025001
protein coding gene Chr19:56379556-56417970 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025684
protein coding gene Chr19:58633717-58673224 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023096
protein coding gene Chr19:53347413-53387001 (+)
CAST/EiJ MGP_CASTEiJ_G0024466
protein coding gene Chr19:56404305-56445544 (+)
CBA/J MGP_CBAJ_G0024981
protein coding gene Chr19:61541780-61581686 (+)
DBA/2J MGP_DBA2J_G0025113
protein coding gene Chr19:54207783-54245746 (+)
FVB/NJ MGP_FVBNJ_G0025074
protein coding gene Chr19:53916091-53954708 (+)
LP/J MGP_LPJ_G0025199
protein coding gene Chr19:57109238-57150345 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025107
protein coding gene Chr19:60801070-60844462 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025742
protein coding gene Chr19:56350278-56388768 (+)
PWK/PhJ MGP_PWKPhJ_G0024214
protein coding gene Chr19:54176503-54214832 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024017
protein coding gene Chr19:55028811-55066816 (+)
WSB/EiJ MGP_WSBEiJ_G0024536
protein coding gene Chr19:56488561-56526026 (+)



Homology
more
  • Human Ortholog
    VWA2, von Willebrand factor A domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VWA2, von Willebrand factor A domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMACO, CCSP-2, NET42
  • Links
    NCBI Gene ID: 340706
    neXtProt AC: NX_Q5GFL6
    UniProt: Q5GFL6

  • Chr Location
    10q25.3; chr10:114239254-114294500 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 18238
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VWA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 240675 NCBI Gene Model | MGI Sequence Detail 37663 C57BL/6J ±  kb
transcript NM_172840 RefSeq | MGI Sequence Detail 3885 Not Specified  
polypeptide Q70UZ7 UniProt | EBI | MGI Sequence Detail 791 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 18
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:87179 Sengle G, et al., Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney. J Biol Chem. 2003 Dec 12;278(50):50240-9
  • Latest
    J:208091 Richardson RJ, et al., AMACO Is a Component of the Basement Membrane-Associated Fraser Complex. J Invest Dermatol. 2014 May;134(5):1313-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory