About   Help   FAQ
Vwa2 Gene Detail
Summary
  • Symbol
    Vwa2
  • Name
    von Willebrand factor A domain containing 2
  • Synonyms
    Amaco
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684334
    NCBI Gene: 240675
  • Gene Overview
    MyGene.info: VWA2
Location & Maps
more
  • Sequence Map
    Chr19:56874249-56912078 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37830 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 52.02 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    VWA2, von Willebrand factor A domain containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VWA2, von Willebrand factor A domain containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMACO, CCSP-2, NET42
  • Links
    NCBI Gene ID: 340706
    neXtProt AC: NX_Q5GFL6

  • Chr Location
    10q25.3; chr10:114239137-114294500 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 18238
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: VWA2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028252 VEGA Gene Model | MGI Sequence Detail 37830 C57BL/6J ±  kb
transcript OTTMUST00000070005 VEGA | MGI Sequence Detail 4049 Not Applicable  
polypeptide OTTMUSP00000035625 VEGA | MGI Sequence Detail 791 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    281 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031522 von Willebrand factor A domain-containing protein 2
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR030755 von Willebrand factor A domain-containing protein 2
    IPR002035 von Willebrand factor, type A
Molecular
Reagents
less
  • All nucleic 20
    Genomic 1
    cDNA 18
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 27
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:87179 Sengle G, et al., Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney. J Biol Chem. 2003 Dec 12;278(50):50240-9
  • Latest
    J:208091 Richardson RJ, et al., AMACO Is a Component of the Basement Membrane-Associated Fraser Complex. J Invest Dermatol. 2014 May;134(5):1313-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory