Slc39a2 MGI Mouse Gene Detail - MGI:2684326 - solute carrier family 39 (zinc transporter), member 2

Symbol

Slc39a2
Name

solute carrier family 39 (zinc transporter), member 2
Synonyms

F730005G13Rik, zip2

Feature Type

protein coding gene
IDs

MGI:2684326
NCBI Gene: 214922
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:52130539-52134202 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 26.71 cM
Mapping Data

1 experiment

SNPs within 2kb

73 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2684326	protein coding gene	Chr14:52130346-52134202 (+)
129S1/SvImJ	ENSMUSG00200016235	protein coding gene	Chr14:40929506-40932771 (+)
A/J	ENSMUSG00195021046	protein coding gene	Chr14:41158559-41161824 (+)
AKR/J	ENSMUSG00220037682	protein coding gene	Chr14:40514453-40517718 (+)
BALB/cJ	ENSMUSG00180043487	protein coding gene	Chr14:40787545-40790810 (+)
C3H/HeJ	ENSMUSG00175049174	protein coding gene	Chr14:42441738-42445003 (+)
C57BL/6NJ	ENSMUSG00215018003	protein coding gene	Chr14:41141552-41144688 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019227	protein coding gene	Chr14:43910963-43914837 (+)
CAST/EiJ	ENSTCUG00005045911	protein coding gene	Chr14:43003169-43006440 (+)
CBA/J	ENSMUSG00210033860	protein coding gene	Chr14:41141193-41144458 (+)
DBA/2J	ENSMUSG00185052193	protein coding gene	Chr14:46059527-46062792 (+)
FVB/NJ	ENSMUSG00205044792	protein coding gene	Chr14:40386298-40389553 (+)
JF1/MsJ	ENSUMUG00000039662	protein coding gene	Chr14:57969539-57972813 (+)
LP/J	ENSMUSG00230052623	protein coding gene	Chr14:58304311-58307441 (+)
NOD/ShiLtJ	ENSMUSG00190028534	protein coding gene	Chr14:40820759-40824014 (+)
NZO/HlLtJ	ENSMUSG00225049691	protein coding gene	Chr14:48602394-48605524 (+)
PWK/PhJ	ENSLUMG00010035739	protein coding gene	Chr14:40354247-40357512 (+)
SPRET/EiJ	ENSMSPG00010042477	protein coding gene	Chr14:44052816-44055676 (+)
WSB/EiJ	ENSIUOG00005032909	protein coding gene	Chr14:40541916-40545165 (+)

Human Ortholog

SLC39A2, solute carrier family 39 member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC39A2, solute carrier family 39 member 2
Synonyms

6A1, ETI-1, ZIP-2, ZIP2
Links

HGNC:17127

NCBI Gene ID: 29986

UniProt: Q9NP94
Chr Location

14q11.2; chr14:20999255-21001871 (+) GRCh38

MGI Vertebrate Homology

Slc39a2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC39A2
Gene Tree

Slc39a2

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Slc39a2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele are overtly normal when fed a zinc-replete diet but show increased sensitivity to the effects of maternal dietary zinc deficiency during pregnancy. Resulting embryos are often growth retarded with craniofacial and limb defects, and show altered iron and calcium levels.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

656
Tissues

30
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc39a2

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All Sequences

37
RefSeq

6
UniProt

1
CCDS

CCDS36914.1

Ensembl

ENSMUSG00000072572 (Evidence)
NCBI Gene

214922

			Length	Strain/Species	Flank
genomic	214922	NCBI Gene Model \| MGI Sequence Detail	3664	C57BL/6J	± kb
transcript	NM_001039676	RefSeq \| MGI Sequence Detail	2334	C57BL/6
polypeptide	G3X943	UniProt \| EBI \| MGI Sequence Detail	309	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015129 zinc transporter ZIP2

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 11

cDNA 7

Primer pair 4

Microarray probesets 2

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MGI:2685135, MGI:2686635

Summaries

All 36

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 7
Earliest

J:87178 Dufner-Beattie J, et al., Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
Latest

J:297328 Zhang Q, et al., SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019 Jan;5(1):eaau9780

TSS for Slc39a2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125431	Chr14:52131089-52131134 (+)	573 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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