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Slc39a2
Gene Detail
Symbol

Name
ID
Slc39a2
solute carrier family 39 (zinc transporter), member 2
MGI:2684326
Synonyms
F730005G13Rik, zip2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:51892889-51896745 bp, + strand
From VEGA annotation of GRCm38

  3857 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SLC39A2
Gene Tree: Slc39a2

Human
homologs
SLC39A2, solute carrier family 39 (zinc transporter), member 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29986
neXtProt AC: NX_Q9NP94

Human Synonyms: 6A1, ETI-1, ZIP2, ZIP-2

Human Chr (Location): 14q11.2; chr14:20999255-21001875 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele are overtly normal when fed a zinc-replete diet but show increased sensitivity to the effects of maternal dietary zinc deficiency during pregnancy. Resulting embryos are often growth retarded with craniofacial and limb defects, and show altered iron and calcium levels.
 
Interactions
Slc39a2 interacts with 184 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (30)    Tissues (18)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 24
RT-PCR 6
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc39a2    NEW 
Molecular
reagents
All nucleic(9) cDNA(5) Primer pair(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000034666 (Evidence)
Ensembl Gene Model ENSMUSG00000072572 (Evidence)
Entrez Gene 214922 (Evidence)
UniGene 281343
DFCI TC1586716
DoTS DT.101345497, DT.101371931, DT.99852534
NIA Mouse Gene Index U374315
Consensus CDS Project CCDS36914.1
International Mouse Phenotyping Consortium Status Slc39a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034666 VEGA Gene Model | MGI Sequence Detail 3857 C57BL/6J ±  kb
transcript OTTMUST00000087987 VEGA | MGI Sequence Detail 2334 Not Applicable 
polypeptide OTTMUSP00000047931 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003689 Zinc/iron permease
Protein Ontology PR:000015129 zinc transporter ZIP2
References
(Earliest) J:87178 Dufner-Beattie J, et al., Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
(Latest) J:148650 Kambe T, et al., Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1474-81
All references(25)
Other
accession IDs
MGI:2685135, MGI:2686635

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory