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Slc39a2 Gene Detail
Summary
  • Symbol
    Slc39a2
  • Name
    solute carrier family 39 (zinc transporter), member 2
  • Synonyms
    F730005G13Rik, zip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684326
    NCBI Gene: 214922
  • Gene Overview
    MyGene.info: SLC39A2
Location & Maps
more
  • Sequence Map
    Chr14:51892889-51896745 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3857 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC39A2, solute carrier family 39 member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLC39A2, solute carrier family 39 member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    6A1, ETI-1, ZIP2, ZIP-2
  • Links
    NCBI Gene ID: 29986
    neXtProt AC: NX_Q9NP94

  • Chr Location
    14q11.2; chr14:20999255-21001875 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc39a2
  • Incidental Mutations
Homozygotes for a null allele are overtly normal when fed a zinc-replete diet but show increased sensitivity to the effects of maternal dietary zinc deficiency during pregnancy. Resulting embryos are often growth retarded with craniofacial and limb defects, and show altered iron and calcium levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034666 VEGA Gene Model | MGI Sequence Detail 3857 C57BL/6J ±  kb
transcript OTTMUST00000087987 VEGA | MGI Sequence Detail 2334 Not Applicable  
polypeptide OTTMUSP00000047931 VEGA | MGI Sequence Detail 309 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    83 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR003689 Zinc/iron permease
Molecular
Reagents
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  • All nucleic 9
    cDNA 5
    Primer pair 4

    Microarray probesets 2
Other
Accession IDs
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MGI:2685135, MGI:2686635
References
more
  • Summaries
    All 22
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:87178 Dufner-Beattie J, et al., Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J Biol Chem. 2003 Dec 12;278(50):50142-50
  • Latest
    J:148650 Kambe T, et al., Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency. Am J Physiol Regul Integr Comp Physiol. 2008 May;294(5):R1474-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory