Tusc1 Gene Detail

Summary

• Symbol
  Tusc1
• Name
  tumor suppressor candidate 1
• Synonyms
  2200001D17Rik, TSG-9

• Feature Type
  protein coding gene
• IDs
  MGI:2684283
  NCBI Gene: 69136

Location & Maps

• Sequence Map
  Chr4:93334138-93335511 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    1374 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 43.25 cM, cytoband C5
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  TUSC1, tumor suppressor candidate 1

• Vertebrate Orthologs
  5

• Human Ortholog
  TUSC1, tumor suppressor candidate 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  CCDC89B, TSG9, TSG-9
• Links
  HGNC:31010

  NCBI Gene ID: 286319

  neXtProt AC: NX_Q2TAM9

  UniProt: Q2TAM9

  
  
• Chr Location
  9p21.2; chr9:25676389-25678858 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 84597
  1 human;1 mouse;1 chimpanzee;1 cattle;1 macaque, rhesus
  
• HCOP
  human homology predictions: TUSC1
• Gene Tree
  Tusc1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotype references
  

• All Mutations and Alleles
  4
• Chemically induced (other)
  2
• Endonuclease-mediated
  1
• Radiation induced
  1
• Genomic Mutations
  3 involving Tusc1
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  5

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Tusc1 interacts with 80 markers (Mir15a, Mir28b, Mir28c, ...) View All

Sequences &
Gene Models

• All Sequences
  15
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS18357.1
• UniGene
  171558

• VEGA
  OTTMUSG00000007809 (Evidence)
• Ensembl
  ENSMUSG00000054000 (Evidence)
• NCBI Gene
  69136

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000007809	VEGA Gene Model | MGI Sequence Detail	1374	C57BL/6J
transcript	OTTMUST00000017798	VEGA | MGI Sequence Detail	1374	Not Applicable
polypeptide	OTTMUSP00000008187	VEGA | MGI Sequence Detail	205	Not Applicable

Polymorphisms

• SNPs within 2kb
  63 from dbSNP Build 142

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000016838 tumor suppressor candidate gene 1 protein
  (term hierarchy)

Molecular
Reagents

• All nucleic 6

  Genomic 1

  cDNA 5

  
  

  Microarray probesets 3

Other
Accession IDs

MGI:1916386

References

• Summaries
  All 25

  Phenotypes 4
• Earliest
  J:23094 Davisson MT, New chromosome aberrations. Mouse News Lett. 1988;80:166
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582