Tbpl2
Gene Detail

Symbol Name ID

Tbpl2 TATA box binding protein like 2 MGI:2684058

Synonyms

LOC227606, Trf3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

16.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:24071721-24096595 bp, - strand From VEGA annotation of GRCm38   24875 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:133152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TATA-box binding protein
Gene Tree: Tbpl2

Human homologs

Human Homolog		TBPL2, TATA box binding protein like 2
NCBI Gene ID		387332
neXtProt AC		NX_Q6SJ96
Human Synonyms		TBP2, TRF3
Human Chr (Location)		14q22.3; chr14:55880928-55907263 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Female mice homozygous for a knock-out allele exhibit infertility due to impaired folliculogenesis before or during secondary follicle development.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	DNA-dependent transcription, initiation, multicellular organismal development, ...
Component	cytoplasm, nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (117)    Images (7)
Theiler Stages: 1, 5, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	95
RT-PCR	45

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(4) Primer pair(3)
Microarray probesets(1)

Other database links

VEGA Gene Model	OTTMUSG00000011801 (Evidence)
Ensembl Gene Model	ENSMUSG00000061809 (Evidence)
Entrez Gene	227606 (Evidence)
UniGene	301625
DFCI	TC1594920
DoTS	DT.102538842
NIA Mouse Gene Index	U171537
Consensus CDS Project	CCDS15732.1
International Mouse Knockout Project Status	Tbpl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011801	VEGA Gene Model | MGI Sequence Detail	24875	C57BL/6J
transcript	OTTMUST00000027700	VEGA | MGI Sequence Detail	1379	Not Applicable
polypeptide	OTTMUSP00000012591	VEGA | MGI Sequence Detail	350	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(91 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012295	Beta2-adaptin/TBP, C-terminal domain
InterPro	IPR000814	TATA-box binding protein
Protein Ontology	PR:000016139	TATA box-binding protein-like protein 2

References

(Earliest) J:87288 Persengiev SP, et al., TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:2685194