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Tbpl2 Gene Detail
Summary
  • Symbol
    Tbpl2
  • Name
    TATA box binding protein like 2
  • Synonyms
    LOC227606, Trf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2684058
    NCBI Gene: 227606
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr2:24071721-24096595 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 16.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2684058
protein coding gene Chr2:24071366-24096595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025402
protein coding gene Chr2:21846300-21872154 (-)
A/J MGP_AJ_G0025380
protein coding gene Chr2:21004992-21030399 (-)
AKR/J MGP_AKRJ_G0025349
protein coding gene Chr2:21703079-21728002 (-)
BALB/cJ MGP_BALBcJ_G0025375
protein coding gene Chr2:21117435-21147407 (-)
C3H/HeJ MGP_C3HHeJ_G0025136
protein coding gene Chr2:21654465-21681578 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025819
protein coding gene Chr2:22522992-22551773 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023231
protein coding gene Chr2:19967970-19987107 (-)
CAST/EiJ MGP_CASTEiJ_G0024599
protein coding gene Chr2:21527532-21552964 (-)
CBA/J MGP_CBAJ_G0025114
protein coding gene Chr2:23361923-23391853 (-)
DBA/2J MGP_DBA2J_G0025247
protein coding gene Chr2:20883774-20909211 (-)
FVB/NJ MGP_FVBNJ_G0025209
protein coding gene Chr2:20611510-20636289 (-)
LP/J MGP_LPJ_G0025333
protein coding gene Chr2:21780749-21809008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025240
protein coding gene Chr2:23543510-23569261 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025878
protein coding gene Chr2:21644994-21672757 (-)
PWK/PhJ MGP_PWKPhJ_G0024348
protein coding gene Chr2:20672562-20697676 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024148
protein coding gene Chr2:21768233-21794701 (-)
WSB/EiJ MGP_WSBEiJ_G0024669
protein coding gene Chr2:21731013-21759000 (-)



Homology
more
  • Human Ortholog
    TBPL2, TATA-box binding protein like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TBPL2, TATA-box binding protein like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TBP2, TRF3
  • Links
    NCBI Gene ID: 387332
    neXtProt AC: NX_Q6SJ96
    UniProt: Q6SJ96

  • Chr Location
    14q22.3; chr14:55414210-55440545 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for a knock-out allele exhibit infertility due to impaired folliculogenesis before or during secondary follicle development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061809 Ensembl Gene Model | MGI Sequence Detail 24875 C57BL/6J ±  kb
    transcript ENSMUST00000080453 Ensembl | MGI Sequence Detail 1379 Not Applicable  
    polypeptide ENSMUSP00000079309 Ensembl | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 5
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685194
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:87288 Persengiev SP, et al., TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91
    • Latest
      J:231014 Malecova B, et al., TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells. Elife. 2016;5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory