About   Help   FAQ
Tbpl2
Gene Detail
Symbol

Name
ID
Tbpl2
TATA box binding protein like 2
MGI:2684058
Synonyms
LOC227606, Trf3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
16.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:24071721-24096595 bp, - strand
From VEGA annotation of GRCm38

  24875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133152  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TATA-box binding protein
Gene Tree: Tbpl2

Human
homologs
Human Homolog TBPL2, TATA box binding protein like 2
NCBI Gene ID 387332
neXtProt AC  NX_Q6SJ96
Human Synonyms  TBP2, TRF3
Human Chr (Location)  14q22.3; chr14:55414210-55440545 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Female mice homozygous for a knock-out allele exhibit infertility due to impaired folliculogenesis before or during secondary follicle development.
 
Interactions
Tbpl2 interacts with 48 markers (Mir10a, Mir10b, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process DNA-templated transcription, initiation, multicellular organismal development, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (119)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 45
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(4) Primer pair(3)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000011801 (Evidence)
Ensembl Gene ModelENSMUSG00000061809 (Evidence)
Entrez Gene227606 (Evidence)
UniGene301625
DFCITC1594920
DoTSDT.102538842
NIA Mouse Gene IndexU171537
Consensus CDS ProjectCCDS15732.1
International Mouse Knockout Project StatusTbpl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011801 VEGA Gene Model | MGI Sequence Detail 24875 C57BL/6J ±  kb
transcript OTTMUST00000027700 VEGA | MGI Sequence Detail 1379 Not Applicable 
polypeptide OTTMUSP00000012591 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(5) UniProt(5)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012295 Beta2-adaptin/TBP, C-terminal domain
InterPro IPR000814 TATA-box binding protein
Protein Ontology PR:000016139 TATA box-binding protein-like protein 2
References
(Earliest) J:87288 Persengiev SP, et al., TRF3, a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14887-91
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2685194

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory