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Klhl41 Gene Detail
Summary
  • Symbol
    Klhl41
  • Name
    kelch-like 41
  • Synonyms
    Kbtbd10, LOC228003
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683854
    NCBI Gene: 228003
  • Gene Overview
    MyGene.info: KLHL41
Location & Maps
more
  • Sequence Map
    Chr2:69670120-69684230 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 40.92 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KLHL41, kelch like family member 41
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLHL41, kelch like family member 41
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KBTBD10, Krp1, SARCOSIN
  • Links
    NCBI Gene ID: 10324
    neXtProt AC: NX_O60662
    UniProt: O60662

  • Chr Location
    2q31.1; chr2:169509702-169526262 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KLHL41 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Klhl41
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013007 VEGA Gene Model | MGI Sequence Detail 14111 C57BL/6J ±  kb
transcript OTTMUST00000031350 VEGA | MGI Sequence Detail 2529 Not Applicable  
polypeptide OTTMUSP00000014018 VEGA | MGI Sequence Detail 606 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    147 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 10
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2684958
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:213890 Gupta VA, et al., Identification of KLHL41 Mutations Implicates BTB-Kelch-Mediated Ubiquitination as an Alternate Pathway to Myofibrillar Disruption in Nemaline Myopathy. Am J Hum Genet. 2013 Dec 5;93(6):1108-17

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory