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Dhps Gene Detail
Summary
  • Symbol
    Dhps
  • Name
    deoxyhypusine synthase
  • Synonyms
    MGC:49129, MGC:74384
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683592
    NCBI Gene: 330817
  • Gene Overview
    MyGene.info: DHPS
Location & Maps
more
  • Sequence Map
    Chr8:85071757-85075162 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3406 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.55 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    DHPS, deoxyhypusine synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHPS, deoxyhypusine synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHS, DS, MIG13
  • Links
    NCBI Gene ID: 1725
    neXtProt AC: NX_P49366

  • Chr Location
    19p13.2; chr19:12672858-12681887 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Dhps
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031492 VEGA Gene Model | MGI Sequence Detail 3406 C57BL/6J ±  kb
transcript OTTMUST00000078026 VEGA | MGI Sequence Detail 1333 Not Applicable  
polypeptide OTTMUSP00000041408 VEGA | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    92 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Gene Ontology 5
    Phenotypes 37
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:207229 Colvin SC, et al., Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes. J Biol Chem. 2013 Dec 20;288(51):36226-35

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory