Dhps MGI Mouse Gene Detail - MGI:2683592

Symbol

Dhps
Name

deoxyhypusine synthase
Synonyms

MGC:49129, MGC:74384

Feature Type

protein coding gene
IDs

MGI:2683592
NCBI Gene: 330817
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:85798386-85801791 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.55 cM
Mapping Data

1 experiment

SNPs within 2kb

188 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2683592	protein coding gene	Chr8:85798106-85801791 (+)
129S1/SvImJ	ENSMUSG00200024503	protein coding gene	Chr8:80163238-80166512 (+)
A/J	ENSMUSG00195015033	protein coding gene	Chr8:80521270-80524539 (+)
AKR/J	ENSMUSG00220022842	protein coding gene	Chr8:80562866-80566139 (+)
BALB/cJ	ENSMUSG00180020030	protein coding gene	Chr8:80361967-80365241 (+)
C3H/HeJ	ENSMUSG00175024590	protein coding gene	Chr8:80456946-80460215 (+)
C57BL/6NJ	ENSMUSG00215010653	protein coding gene	Chr8:80094728-80098134 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031329	protein coding gene	Chr8:76423453-76426970 (+)
CAST/EiJ	ENSTCUG00005036369	protein coding gene	Chr8:79971249-79974656 (+)
CBA/J	ENSMUSG00210030714	protein coding gene	Chr8:80444070-80447339 (+)
DBA/2J	ENSMUSG00185037362	protein coding gene	Chr8:86552658-86555927 (+)
FVB/NJ	ENSMUSG00205035158	protein coding gene	Chr8:79499924-79503193 (+)
JF1/MsJ	ENSUMUG00000020656	protein coding gene	Chr8:88861381-88864787 (+)
LP/J	ENSMUSG00230024556	protein coding gene	Chr8:90160222-90163495 (+)
NOD/ShiLtJ	ENSMUSG00190015177	protein coding gene	Chr8:80520383-80523652 (+)
NZO/HlLtJ	ENSMUSG00225040298	protein coding gene	Chr8:93555417-93558822 (+)
PWK/PhJ	ENSLUMG00010028253	protein coding gene	Chr8:80198375-80201781 (+)
SPRET/EiJ	ENSMSPG00010025554	protein coding gene	Chr8:82110737-82114151 (+)
WSB/EiJ	ENSIUOG00005018338	protein coding gene	Chr8:81257998-81261272 (+)

Human Ortholog

DHPS, deoxyhypusine synthase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DHPS, deoxyhypusine synthase
Synonyms

DHS, DS, MIG13, NEDSSWI
Links

HGNC:2869

NCBI Gene ID: 1725

UniProt: P49366
Chr Location

19p13.13; chr19:12672470-12681894 (-) GRCh38

MGI Vertebrate Homology

Dhps stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DHPS
Gene Tree

Dhps

less

Phenotype Summary

15 phenotypes from 5 alleles in 5 genetic backgrounds
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Dhps
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out or gene trap allele exhibit embryonic lethality prior somite formation.

less

All GO Annotations

26
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

612
Tissues

4
cDNA Data

10
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dhps

ZFIN dhps

less

All Sequences

56
RefSeq

3
UniProt

3
CCDS

CCDS22492.1

Ensembl

ENSMUSG00000060038 (Evidence)
NCBI Gene

330817

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060038	Ensembl Gene Model \| MGI Sequence Detail	3406	C57BL/6J	± kb
transcript	ENSMUST00000078665	Ensembl \| MGI Sequence Detail	1333	Not Applicable
polypeptide	ENSMUSP00000077733	Ensembl \| MGI Sequence Detail	369	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000006461 deoxyhypusine synthase

(term hierarchy)
EC

2.5.1.46
InterPro Domains

IPR002773 Deoxyhypusine synthase

IPR036982 Deoxyhypusine synthase superfamily

IPR029035 DHS-like NAD/FAD-binding domain superfamily

less

All nucleic 10

cDNA 10

Antibodies 1

Microarray probesets 5

Summaries

All 89

Developmental Gene Expression 1

Gene Ontology 12

Phenotypes 57
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:389473 Carrizo GE, et al., The transition from monocyte to tissue-resident macrophage requires DHPS. Nature. 2026 Mar;651(8106):763-774

TSS for Dhps:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78520	Chr8:85798349-85798363 (+)	-30 bp
Tssr78521	Chr8:85798366-85798398 (+)	-4 bp
Tssr78522	Chr8:85798399-85798423 (+)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24