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Dhps Gene Detail
Summary
  • Symbol
    Dhps
  • Name
    deoxyhypusine synthase
  • Synonyms
    MGC:49129, MGC:74384
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683592
    NCBI Gene: 330817
  • Gene Overview
    MyGene.info: DHPS
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85071757-85075162 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 41.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2683592
protein coding gene Chr8:85071486-85075162 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033892
protein coding gene Chr8:86019819-86023092 (+)
A/J MGP_AJ_G0033875
protein coding gene Chr8:82621353-82624622 (+)
AKR/J MGP_AKRJ_G0033801
protein coding gene Chr8:85077247-85080520 (+)
BALB/cJ MGP_BALBcJ_G0033868
protein coding gene Chr8:82755835-82759108 (+)
C3H/HeJ MGP_C3HHeJ_G0033578
protein coding gene Chr8:85696698-85699967 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034388
protein coding gene Chr8:89309760-89313165 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031329
protein coding gene Chr8:76423453-76426970 (+)
CAST/EiJ MGP_CASTEiJ_G0032908
protein coding gene Chr8:85127087-85130494 (+)
CBA/J MGP_CBAJ_G0033554
protein coding gene Chr8:92340553-92343822 (+)
DBA/2J MGP_DBA2J_G0033707
protein coding gene Chr8:82258790-82262059 (+)
FVB/NJ MGP_FVBNJ_G0033655
protein coding gene Chr8:81218024-81221528 (+)
LP/J MGP_LPJ_G0033799
protein coding gene Chr8:86128944-86132217 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033697
protein coding gene Chr8:94902649-94905918 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034405
protein coding gene Chr8:85067547-85070952 (+)
PWK/PhJ MGP_PWKPhJ_G0032611
protein coding gene Chr8:81505842-81509248 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032448
protein coding gene Chr8:83885550-83888964 (+)
WSB/EiJ MGP_WSBEiJ_G0033021
protein coding gene Chr8:85493327-85496601 (+)



Homology
more
  • Human Ortholog
    DHPS, deoxyhypusine synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DHPS, deoxyhypusine synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DHS, DS, MIG13, NEDSSWI
  • Links
    NCBI Gene ID: 1725
    neXtProt AC: NX_P49366
    UniProt: P49366

  • Chr Location
    19p13.13; chr19:12672164-12681887 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality prior to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060038 Ensembl Gene Model | MGI Sequence Detail 3406 C57BL/6J ±  kb
    transcript ENSMUST00000078665 Ensembl | MGI Sequence Detail 1333 Not Applicable  
    polypeptide ENSMUSP00000077733 Ensembl | MGI Sequence Detail 369 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 5
    References
    more
    • Summaries
      All 65
      Gene Ontology 6
      Phenotypes 41
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:282477 Baldelomar EJ, et al., In vivo measurements of kidney glomerular number and size in healthy and Os(/+) mice using MRI. Am J Physiol Renal Physiol. 2019 Oct 1;317(4):F865-F873

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/03/2020
    MGI 6.15
    The Jackson Laboratory