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Tapt1 Gene Detail
Summary
  • Symbol
    Tapt1
  • Name
    transmembrane anterior posterior transformation 1
  • Synonyms
    4932414K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683537
    NCBI Gene: 231225
Location & Maps
more
  • Sequence Map
    Chr5:44175154-44226626 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51473 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 24.24 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TAPT1, transmembrane anterior posterior transformation 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TAPT1, transmembrane anterior posterior transformation 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMVFR, OCLSBG
  • Links
    NCBI Gene ID: 202018
    neXtProt AC: NX_Q6NXT6

  • Chr Location
    4p15.32; chr4:16160505-16227158 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 80206
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: TAPT1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TAPT1 associations

Human Disease Mouse Models
       Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type;   OMIM: 616897
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Gene trapped
    4
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    6 involving Tapt1
  • Incidental Mutations
Mice homozygous for an ENU mutation causing a truncation exhibit vertebral trasnformations and defects in rib attachment and the xiphoid process. Mice homozygous for a transgenic gene disruption exhibit cleft palate and possible anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053809 VEGA Gene Model | MGI Sequence Detail 51473 C57BL/6J ±  kb
transcript OTTMUST00000133938 VEGA | MGI Sequence Detail 3513 Not Applicable  
polypeptide OTTMUSP00000071117 VEGA | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    285 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016055 transmembrane anterior posterior transformation protein 1
  • InterPro Domains
    IPR008010 Tapt1 family
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory