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Ttll6 Gene Detail
Summary
  • Symbol
    Ttll6
  • Name
    tubulin tyrosine ligase-like family, member 6
  • Synonyms
    4932418K24Rik, D11Moh43e, D11Moh44e, t8130b59
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683461
    NCBI Gene: 237930
Location & Maps
more
  • Sequence Map
    Chr11:96133786-96165451 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31666 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.48 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTLL6, tubulin tyrosine ligase like 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TTLL6, tubulin tyrosine ligase like 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TTL.6
  • Links
    NCBI Gene ID: 284076
    neXtProt AC: NX_Q8N841

  • Chr Location
    17q21.32; chr17:48762231-48817107 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotype references
  • All Mutations and Alleles
    18
  • Endonuclease-mediated
    1
  • Gene trapped
    12
  • Targeted
    5
  • Genomic Mutations
    2 involving Ttll6
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001959 VEGA Gene Model | MGI Sequence Detail 31666 C57BL/6J ±  kb
transcript OTTMUST00000062894 VEGA | MGI Sequence Detail 3205 Not Applicable  
polypeptide OTTMUSP00000031068 VEGA | MGI Sequence Detail 822 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    235 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016795 tubulin polyglutamylase TTLL6
  • EC
  • InterPro Domains
    IPR027754 Tubulin polyglutamylase TTLL6
    IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
Molecular
Reagents
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  • All nucleic 17
    Genomic 6
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:1343167, MGI:1343181
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:51104 Mohlke KL, et al., Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Genomics. 1998 Nov 15;54(1):19-30
  • Latest
    J:231311 Xia P, et al., Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Apr;17(4):369-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory