Ifnk MGI Mouse Gene Detail - MGI:2683287

Symbol

Ifnk
Name

interferon kappa

Feature Type

protein coding gene
IDs

MGI:2683287
NCBI Gene: 387510
Alliance

gene page

Sequence Map

Chr4:35152056-35154005 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 17.08 cM
Mapping Data

1 experiment

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2683287	protein coding gene	Chr4:35152055-35154019 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028136	protein coding gene	Chr4:32772047-32773996 (+)
A/J	MGP_AJ_G0028094	protein coding gene	Chr4:31575860-31577731 (+)
AKR/J	MGP_AKRJ_G0028057	protein coding gene	Chr4:32414038-32415909 (+)
BALB/cJ	MGP_BALBcJ_G0028106	protein coding gene	Chr4:31852491-31854440 (+)
C3H/HeJ	MGP_C3HHeJ_G0027834	protein coding gene	Chr4:32737179-32739050 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028547	protein coding gene	Chr4:34024322-34026271 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025888	protein coding gene	Chr4:29659754-29661966 (+)
CAST/EiJ	MGP_CASTEiJ_G0027290	protein coding gene	Chr4:32529944-32531822 (+)
CBA/J	MGP_CBAJ_G0027806	protein coding gene	Chr4:35139962-35141833 (+)
DBA/2J	MGP_DBA2J_G0027950	protein coding gene	Chr4:31542099-31543970 (+)
FVB/NJ	MGP_FVBNJ_G0027917	protein coding gene	Chr4:30961954-30963825 (+)
LP/J	MGP_LPJ_G0028058	protein coding gene	Chr4:32878780-32880729 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027950	protein coding gene	Chr4:37750070-37751941 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028606	protein coding gene	Chr4:32436056-32438005 (+)
PWK/PhJ	MGP_PWKPhJ_G0027008	protein coding gene	Chr4:31581614-31583610 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026837	protein coding gene	Chr4:32305088-32307062 (+)
WSB/EiJ	MGP_WSBEiJ_G0027366	protein coding gene	Chr4:32433922-32435793 (+)

Human Ortholog

IFNK, interferon kappa

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFNK, interferon kappa
Synonyms

IFNT1, INFE1
Links

HGNC:21714

NCBI Gene ID: 56832

neXtProt AC: NX_Q9P0W0

UniProt: Q9P0W0
Chr Location

chr9:27524290-27526498 (+) GRCh38

MGI Vertebrate Homology

Ifnk stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IFNK
Gene Tree

Ifnk

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Phenotype Summary

3 phenotypes from 1 allele in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically and radiation induced

1
Endonuclease-mediated

3
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Ifnk
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit resistance to IMQ-induced psoriasis.

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All GO Annotations

16
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

14
cDNA Data

3
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

2
CCDS

CCDS18037.1

Ensembl

ENSMUSG00000042993 (Evidence)
NCBI Gene

387510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042993	Ensembl Gene Model \| MGI Sequence Detail	1950	C57BL/6J	± kb
transcript	ENSMUST00000058595	Ensembl \| MGI Sequence Detail	805	Not Applicable
polypeptide	ENSMUSP00000054273	Ensembl \| MGI Sequence Detail	199	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008927 interferon kappa

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR000471 Interferon alpha/beta/delta

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All nucleic 3

cDNA 3

Microarray probesets 1

Summaries

All 26

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 10
Earliest

J:83469 Vassileva G, et al., Expression of a novel murine type I IFN in the pancreatic islets induces diabetes in mice. J Immunol. 2003 Jun 1;170(11):5748-55
Latest

J:322130 Gharaee-Kermani M, et al., IFN-kappa Is a Rheostat for Development of Psoriasiform Inflammation. J Invest Dermatol. 2022 Jan;142(1):155-165.e3

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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