Zhx2 MGI Mouse Gene Detail - MGI:2683087 - zinc fingers and homeoboxes 2

Zhx2 Gene Detail

Symbol

Zhx2
Name

zinc fingers and homeoboxes 2
Synonyms

Afr1, Afr-1, mKIAA0854, Raf

Feature Type

protein coding gene
IDs

MGI:2683087
NCBI Gene: 387609
Gene Overview

MyGene.info: ZHX2

Sequence Map

Chr15:57694665-57839832 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

145168 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.01 cM
Mapping Data

10 experiments

Human Ortholog

ZHX2, zinc fingers and homeoboxes 2

Vertebrate Orthologs

9

Human Ortholog

ZHX2, zinc fingers and homeoboxes 2
Orthology source: HomoloGene, HGNC
Synonyms

AFR1, RAF
Links

HGNC:18513

NCBI Gene ID: 22882

neXtProt AC: NX_Q9Y6X8

UniProt: Q9Y6X8
Chr Location

8q24.13; chr8:122781349-122974515 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8968
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ZHX2
Gene Tree

Zhx2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

3
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

4 involving Zhx2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

Alpha-fetoprotein levels in plasma decline precipitously after birth. This gene regulates a difference in adult level and rate of neonatal decrease of AFP. The BALB/cJ substrain carries a genetic variant allele determining a slow rate of decline to adultlevel.

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All GO Annotations

27
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

24
Tissues

15
cDNA Data

34
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zhx2

ZFIN zhx2a

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Zhx2 interacts with 209 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

25
RefSeq

6
UniProt

2
CCDS

CCDS27483.1
UniGene

36557

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028875	VEGA Gene Model \| MGI Sequence Detail	145168	C57BL/6J	± kb
transcript	OTTMUST00000071525	VEGA \| MGI Sequence Detail	4376	Not Applicable
polypeptide	OTTMUSP00000036655	VEGA \| MGI Sequence Detail	836	Not Applicable

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SNPs within 2kb

1035 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000017663 zinc fingers and homeoboxes protein 2

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR009057 Homeobox domain-like

IPR013087 Zinc finger C2H2-type

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All nucleic 34

cDNA 34

Microarray probesets 2

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MGD-MRK-1174, MGD-MRK-1176, MGD-MRK-13750, MGI:87952

Summaries

All 56

Developmental Gene Expression 3

Diseases 1

Gene Ontology 12

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:198271 Lin CY, et al., Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy. PLoS One. 2013;8(2):e56731

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/20/2017 MGI 6.10