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Zhx2 Gene Detail
Summary
  • Symbol
    Zhx2
  • Name
    zinc fingers and homeoboxes 2
  • Synonyms
    Afr1, Afr-1, mKIAA0854, Raf
  • Feature Type
    protein coding gene
  • IDs
    MGI:2683087
    NCBI Gene: 387609
  • Gene Overview
    MyGene.info: ZHX2
Location & Maps
more
  • Sequence Map
    Chr15:57694665-57839832 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      145168 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 24.01 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    ZHX2, zinc fingers and homeoboxes 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZHX2, zinc fingers and homeoboxes 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFR1, RAF
  • Links
    NCBI Gene ID: 22882
    neXtProt AC: NX_Q9Y6X8

  • Chr Location
    8q24.13; chr8:122781349-122974515 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 8968
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ZHX2
  • Gene Tree
    Zhx2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    3
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Zhx2
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Alpha-fetoprotein levels in plasma decline precipitously after birth. This gene regulates a difference in adult level and rate of neonatal decrease of AFP. The BALB/cJ substrain carries a genetic variant allele determining a slow rate of decline to adultlevel.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    24
  • Tissues
    15
  • cDNA Data
    34
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028875 VEGA Gene Model | MGI Sequence Detail 145168 C57BL/6J ±  kb
transcript OTTMUST00000071525 VEGA | MGI Sequence Detail 4376 Not Applicable  
polypeptide OTTMUSP00000036655 VEGA | MGI Sequence Detail 836 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1035 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-1174, MGD-MRK-1176, MGD-MRK-13750, MGI:87952
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:5803 Olsson M, et al., Genetic control of alpha-fetoprotein synthesis in the mouse. J Exp Med. 1977 Apr 1;145(4):819-27
  • Latest
    J:198271 Lin CY, et al., Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy. PLoS One. 2013;8(2):e56731
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory