Zhx2 MGI Mouse Gene Detail - MGI:2683087 - zinc fingers and homeoboxes 2

Symbol

Zhx2
Name

zinc fingers and homeoboxes 2
Synonyms

Afr-1, Afr1, mKIAA0854, Raf

Feature Type

protein coding gene
IDs

MGI:2683087
NCBI Gene: 387609
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr15:57558063-57703228 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 24.01 cM
Mapping Data

10 experiments

SNPs within 2kb

7361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2683087	protein coding gene	Chr15:57558061-57703228 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021861	protein coding gene	Chr15:56831064-56988681 (+)
A/J	MGP_AJ_G0021821	protein coding gene	Chr15:54601930-54750809 (+)
AKR/J	MGP_AKRJ_G0021802	protein coding gene	Chr15:56095047-56241303 (+)
BALB/cJ	MGP_BALBcJ_G0021828	protein coding gene	Chr15:54829028-54977446 (+)
C3H/HeJ	MGP_C3HHeJ_G0021602	protein coding gene	Chr15:56235599-56393744 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022267	protein coding gene	Chr15:59054044-59208992 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019804	protein coding gene	Chr15:51704166-51846104 (+)
CAST/EiJ	MGP_CASTEiJ_G0021119	protein coding gene	Chr15:56847045-57013211 (+)
CBA/J	MGP_CBAJ_G0021571	protein coding gene	Chr15:61101635-61272632 (+)
DBA/2J	MGP_DBA2J_G0021695	protein coding gene	Chr15:54529668-54676754 (+)
FVB/NJ	MGP_FVBNJ_G0021673	protein coding gene	Chr15:53580119-53726348 (+)
LP/J	MGP_LPJ_G0021765	protein coding gene	Chr15:56678490-56834691 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021697	protein coding gene	Chr15:66200999-66357448 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022290	protein coding gene	Chr15:56523189-56683174 (+)
PWK/PhJ	MGP_PWKPhJ_G0020864	protein coding gene	Chr15:54526313-54661729 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020701	protein coding gene	Chr15:56299965-56433814 (+)
WSB/EiJ	MGP_WSBEiJ_G0021174	protein coding gene	Chr15:56497487-56657118 (+)

Human Ortholog

ZHX2, zinc fingers and homeoboxes 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZHX2, zinc fingers and homeoboxes 2
Synonyms

AFR1, RAF
Links

HGNC:18513

NCBI Gene ID: 22882

UniProt: Q9Y6X8
Chr Location

8q24.13; chr8:122780379-122974510 (+) GRCh38

MGI Vertebrate Homology

Zhx2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZHX2
Gene Tree

Zhx2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

3
Endonuclease-mediated

6
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Zhx2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Alpha-fetoprotein levels in plasma decline precipitously after birth. This gene regulates a difference in adult level and rate of neonatal decrease of AFP. The BALB/cJ substrain carries a genetic variant allele determining a slow rate of decline to adultlevel.

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All GO Annotations

46
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

819
Tissues

30
cDNA Data

35
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase zhx2

ZFIN zhx2a

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS27483.1

Ensembl

ENSMUSG00000071757 (Evidence)
NCBI Gene

387609

			Length	Strain/Species	Flank
genomic	387609	NCBI Gene Model \| MGI Sequence Detail	145166	C57BL/6J	± kb
transcript	NM_199449	RefSeq \| MGI Sequence Detail	4392	ZRU/MplStud
polypeptide	Q8C0C0	UniProt \| EBI \| MGI Sequence Detail	836	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017663 zinc fingers and homeoboxes protein 2

(term hierarchy)
InterPro Domains

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR041057 ZHX, C2H2 finger domain

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q8C0C0 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 35

Primer pair 1

Other 1

Microarray probesets 2

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MGD-MRK-1174, MGD-MRK-1176, MGD-MRK-13750, MGI:87952

Summaries

All 84

Developmental Gene Expression 10

Diseases 1

Gene Ontology 17

Phenotypes 31
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:360834 Lynch WB, et al., Validation studies and multi-omics analysis of Zhx2 as a candidate quantitative trait gene underlying brain oxycodone metabolite (oxymorphone) levels and behavior. bioRxiv. 2024 Sep 1;

TSS for Zhx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131310	Chr15:57558047-57558082 (+)	2 bp
Tssr131311	Chr15:57558157-57558173 (+)	102 bp
Tssr131312	Chr15:57558186-57558233 (+)	147 bp
Tssr131313	Chr15:57558235-57558245 (+)	177 bp
Tssr131314	Chr15:57558256-57558266 (+)	198 bp
Tssr131315	Chr15:57558310-57558375 (+)	280 bp
Tssr131316	Chr15:57558613-57558617 (+)	552 bp
Tssr131317	Chr15:57559058-57559081 (+)	1,007 bp
Tssr131318	Chr15:57559086-57559098 (+)	1,029 bp
Tssr131319	Chr15:57640708-57640711 (+)	82,647 bp
Tssr131320	Chr15:57702994-57703000 (+)	144,934 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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