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Enpp4 Gene Detail
Summary
  • Symbol
    Enpp4
  • Name
    ectonucleotide pyrophosphatase/phosphodiesterase 4
  • Synonyms
    4933413N07Rik, LOC224794, MGC:29265
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682634
    NCBI Gene: 224794
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:44096308-44105809 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 20.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682634
 protein coding gene Chr17:44096307-44105809 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023782
 protein coding gene Chr17:45029140-45038615 (-)
A/J MGP_AJ_G0023740
 protein coding gene Chr17:43993090-44002565 (-)
AKR/J MGP_AKRJ_G0023711
 protein coding gene Chr17:44259840-44269324 (-)
BALB/cJ MGP_BALBcJ_G0023744
 protein coding gene Chr17:43872764-43882248 (-)
C3H/HeJ MGP_C3HHeJ_G0023508
 protein coding gene Chr17:44969835-44979319 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024187
 protein coding gene Chr17:47024771-47034272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021637
 protein coding gene Chr17:40816567-40826415 (-)
CAST/EiJ MGP_CASTEiJ_G0022989
 protein coding gene Chr17:45014905-45024432 (-)
CBA/J MGP_CBAJ_G0023484
 protein coding gene Chr17:48670598-48680082 (-)
DBA/2J MGP_DBA2J_G0023610
 protein coding gene Chr17:42797397-42806881 (-)
FVB/NJ MGP_FVBNJ_G0023577
 protein coding gene Chr17:42366908-42376385 (-)
LP/J MGP_LPJ_G0023691
 protein coding gene Chr17:45687151-45696626 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023606
 protein coding gene Chr17:48298295-48307770 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024232
 protein coding gene Chr17:44609906-44619383 (-)
PWK/PhJ MGP_PWKPhJ_G0022734
 protein coding gene Chr17:42061159-42070645 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022549
 protein coding gene Chr17:41473016-41482538 (-)
WSB/EiJ MGP_WSBEiJ_G0023054
 protein coding gene Chr17:45130158-45139629 (-)



Homology
more
  • Human Ortholog
    ENPP4, ectonucleotide pyrophosphatase/phosphodiesterase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENPP4, ectonucleotide pyrophosphatase/phosphodiesterase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NPP4
  • Links
    NCBI Gene ID: 22875
    neXtProt AC: NX_Q9Y6X5
    UniProt: Q9Y6X5

  • Chr Location
    6p21.1; chr6:46129964-46146699 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    656
  • Tissues
    5
  • cDNA Data
    12
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023961 Ensembl Gene Model | MGI Sequence Detail 9502 C57BL/6J ±  kb
    transcript ENSMUST00000024757 Ensembl | MGI Sequence Detail 4560 Not Applicable  
    polypeptide ENSMUSP00000024757 Ensembl | MGI Sequence Detail 456 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000031839 bis(5'-adenosyl)-triphosphatase ENPP4
      (term hierarchy)
    • EC
      3.6.1.29
    • InterPro Domains
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
      IPR029879 Bis(5'-adenosyl)-triphosphatase ENPP4
      IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146787, MGI:2146805, MGI:2684936
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:78525 Lemon WJ, et al., Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. J Med Genet. 2002 Sep;39(9):644-55
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    02/16/2021
    MGI 6.16     		The Jackson Laboratory