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Zc3h4 Gene Detail
Summary
  • Symbol
    Zc3h4
  • Name
    zinc finger CCCH-type containing 4
  • Synonyms
    Bwq1, Kiaa1064-hp, LOC330474, MGC:67629, mKIAA1064
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682314
    NCBI Gene: 330474
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16400910-16437696 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.03 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    199 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682314
 protein coding gene Chr7:16399583-16437696 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031709
 protein coding gene Chr7:14102593-14146563 (+)
A/J MGP_AJ_G0031681
 protein coding gene Chr7:13873320-13910137 (+)
AKR/J MGP_AKRJ_G0031606
 protein coding gene Chr7:14192578-14230493 (+)
BALB/cJ MGP_BALBcJ_G0031688
 protein coding gene Chr7:13981014-14017789 (+)
C3H/HeJ MGP_C3HHeJ_G0031410
 protein coding gene Chr7:14378390-14416439 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032154
 protein coding gene Chr7:14854661-14893870 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029233
 protein coding gene Chr7:15426462-15462728 (+)
CAST/EiJ MGP_CASTEiJ_G0030761
 protein coding gene Chr7:11135014-11171477 (+)
CBA/J MGP_CBAJ_G0031369
 protein coding gene Chr7:15318001-15359942 (+)
DBA/2J MGP_DBA2J_G0031525
 protein coding gene Chr7:13759329-13795860 (+)
FVB/NJ MGP_FVBNJ_G0031481
 protein coding gene Chr7:13655620-13694840 (+)
LP/J MGP_LPJ_G0031610
 protein coding gene Chr7:14355657-14394373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031516
 protein coding gene Chr7:15273817-15311462 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032183
 protein coding gene Chr7:13969537-14006320 (+)
PWK/PhJ MGP_PWKPhJ_G0030485
 protein coding gene Chr7:11281809-11319165 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030312
 protein coding gene Chr7:8882171-8922975 (+)
WSB/EiJ MGP_WSBEiJ_G0030858
 protein coding gene Chr7:14026388-14063818 (+)



Homology
more
  • Human Ortholog
    ZC3H4, zinc finger CCCH-type containing 4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ZC3H4, zinc finger CCCH-type containing 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C19orf7
  • Links
    NCBI Gene ID: 23211
    neXtProt AC: NX_Q9UPT8
    UniProt: Q9UPT8

  • Chr Location
    19q13.32; chr19:47064187-47114436 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation and failure of blastocysts to hatch from the zona pellucida and form typical outgrowth colonies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    27
  • Tissues
    22
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059273 Ensembl Gene Model | MGI Sequence Detail 36787 C57BL/6J ±  kb
    transcript ENSMUST00000098789 Ensembl | MGI Sequence Detail 6039 Not Applicable  
    polypeptide ENSMUSP00000096386 Ensembl | MGI Sequence Detail 1255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 10
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:1298203, MGI:2389001, MGI:2685614
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:48704 Suto J, et al., Genetics of obesity in KK mouse and effects of A(y) allele on quantitative regulation. Mamm Genome. 1998 Jul;9(7):506-10
    • Latest
      J:273830 Yang X, et al., Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. FASEB J. 2018 Jun;32(6):3264-3277
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/03/2019
    MGI 6.14     		The Jackson Laboratory