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Zfp335 Gene Detail
Summary
  • Symbol
    Zfp335
  • Name
    zinc finger protein 335
  • Synonyms
    1810045J01Rik, MGC:86001
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682313
    NCBI Gene: 329559
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:164891882-164911757 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19876 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZNF335, zinc finger protein 335
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNF335, zinc finger protein 335
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCPH10, NIF1, NIF-1, NIF2
  • Links
    NCBI Gene ID: 63925
    neXtProt AC: NX_Q9H4Z2
    UniProt: Q9H4Z2

  • Chr Location
    20q13.12; chr20:45948653-45972910 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ZNF335 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality before implantation. Mice homozygous for a conditional allele activated in the brain exhibit loss of cortical neurons and decreased brain size.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001111 VEGA Gene Model | MGI Sequence Detail 19876 C57BL/6J ±  kb
    transcript OTTMUST00000002179 VEGA | MGI Sequence Detail 4587 Not Applicable  
    polypeptide OTTMUSP00000001064 VEGA | MGI Sequence Detail 1337 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      119 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917051
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:214793 Han BY, et al., Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Elife. 2014;3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory