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Zfp335
Gene Detail
 Symbol
Name
ID
Zfp335
zinc finger protein 335
MGI:2682313
Synonyms 1810045J01Rik, MGC:86001
Feature Type protein coding gene
Genetic Map
Chromosome 2
85.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:164891882-164911757 bp, - strand
From VEGA annotation of GRCm38

  19876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11129  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfp335

Human
homologs
Human Homolog ZNF335, zinc finger protein 335
NCBI Gene ID 63925
neXtProt AC  NX_Q9H4Z2
Human Synonyms  MCPH10, NIF1, NIF-1, NIF2
Human Chr (Location)  20q13.12; chr20:45948653-45972194 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZNF335
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality before implantation. Mice homozygous for a conditional allele activated in the brain exhibit loss of cortical neurons and decreased brain size.
 
Human Diseases Modeled Using Mouse Zfp335 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zfp335 interacts with 80 markers (Mir22, Mir92-2, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process brain development, brain morphogenesis, ...
Component histone methyltransferase complex, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) cDNA(44)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001111 (Evidence)
Ensembl Gene ModelENSMUSG00000039834 (Evidence)
Entrez Gene329559 (Evidence)
UniGene330776
DFCITC1581016, TC1604729
Consensus CDS ProjectCCDS38331.1
International Mouse Knockout Project StatusZfp335
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001111 VEGA Gene Model | MGI Sequence Detail 19876 C57BL/6J ±  kb
transcript OTTMUST00000002179 VEGA | MGI Sequence Detail 4587 Not Applicable 
polypeptide OTTMUSP00000001064 VEGA | MGI Sequence Detail 1337 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(12) UniProt(3)
Polymorphisms SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017836 zinc finger protein 335
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193339 Yang YJ, et al., Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. Cell. 2012 Nov 21;151(5):1097-112
All references(34)
Disease annotation references (1)
Other
accession IDs
MGI:1917051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory