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Zfp335 Gene Detail
Summary
  • Symbol
    Zfp335
  • Name
    zinc finger protein 335
  • Synonyms
    1810045J01Rik, MGC:86001
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682313
    NCBI Gene: 329559
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164891892-164911750 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682313
protein coding gene Chr2:164891882-164911757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026882
protein coding gene Chr2:170404906-170424798 (-)
A/J MGP_AJ_G0026849
protein coding gene Chr2:163430387-163450287 (-)
AKR/J MGP_AKRJ_G0026820
protein coding gene Chr2:168310069-168330207 (-)
BALB/cJ MGP_BALBcJ_G0026858
protein coding gene Chr2:163797438-163817583 (-)
C3H/HeJ MGP_C3HHeJ_G0026600
protein coding gene Chr2:168657574-168678437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027305
protein coding gene Chr2:175344256-175364140 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024676
protein coding gene Chr2:156837862-156859165 (-)
CAST/EiJ MGP_CASTEiJ_G0026058
protein coding gene Chr2:169071488-169091552 (-)
CBA/J MGP_CBAJ_G0026577
protein coding gene Chr2:181708996-181729190 (-)
DBA/2J MGP_DBA2J_G0026715
protein coding gene Chr2:162597173-162617468 (-)
FVB/NJ MGP_FVBNJ_G0026681
protein coding gene Chr2:161019011-161040108 (-)
LP/J MGP_LPJ_G0026817
protein coding gene Chr2:170459576-170481263 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026700
protein coding gene Chr2:185250528-185271767 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027362
protein coding gene Chr2:168194224-168218881 (-)
PWK/PhJ MGP_PWKPhJ_G0025795
protein coding gene Chr2:162200481-162220607 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025596
protein coding gene Chr2:167099711-167119584 (-)
WSB/EiJ MGP_WSBEiJ_G0026131
protein coding gene Chr2:169076730-169099245 (-)



Homology
more
  • Human Ortholog
    ZNF335, zinc finger protein 335
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZNF335, zinc finger protein 335
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCPH10, NIF1, NIF-1, NIF2
  • Links
    NCBI Gene ID: 63925
    neXtProt AC: NX_Q9H4Z2
    UniProt: Q9H4Z2

  • Chr Location
    20q13.12; chr20:45948653-45972910 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ZNF335 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality before implantation. Mice homozygous for a conditional allele activated in the brain exhibit loss of cortical neurons and decreased brain size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 329559 NCBI Gene Model | MGI Sequence Detail 19859 C57BL/6J ±  kb
    transcript NM_199027 RefSeq | MGI Sequence Detail 4610 C57BL/6  
    polypeptide A2A5K6 UniProt | EBI | MGI Sequence Detail 1337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 45

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917051
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:214793 Han BY, et al., Zinc finger protein Zfp335 is required for the formation of the naive T cell compartment. Elife. 2014;3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory