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Ric8b Gene Detail
Summary
  • Symbol
    Ric8b
  • Name
    RIC8 guanine nucleotide exchange factor B
  • Synonyms
    MGC:58970, Ric-8, Ric-8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682307
    NCBI Gene: 237422
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:84917616-85018337 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    265 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682307
protein coding gene Chr10:84917249-85018337 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017595
protein coding gene Chr10:85807971-85906789 (+)
A/J MGP_AJ_G0017575
protein coding gene Chr10:82890812-82989533 (+)
AKR/J MGP_AKRJ_G0017534
protein coding gene Chr10:85198414-85297199 (+)
BALB/cJ MGP_BALBcJ_G0017538
protein coding gene Chr10:83138990-83237922 (+)
C3H/HeJ MGP_C3HHeJ_G0017360
protein coding gene Chr10:85283989-85384404 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017995
protein coding gene Chr10:88713998-88814244 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015679
protein coding gene Chr10:78701231-78799949 (+)
CAST/EiJ MGP_CASTEiJ_G0016927
protein coding gene Chr10:85139378-85241150 (+)
CBA/J MGP_CBAJ_G0017330
protein coding gene Chr10:92421403-92520775 (+)
DBA/2J MGP_DBA2J_G0017436
protein coding gene Chr10:82035230-82134140 (+)
FVB/NJ MGP_FVBNJ_G0017430
protein coding gene Chr10:81268595-81367329 (+)
LP/J MGP_LPJ_G0017508
protein coding gene Chr10:86440109-86540500 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017458
protein coding gene Chr10:94011821-94113739 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018032
protein coding gene Chr10:85116819-85217866 (+)
PWK/PhJ MGP_PWKPhJ_G0016708
protein coding gene Chr10:81896407-81995992 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016497
protein coding gene Chr10:83745315-83844017 (+)
WSB/EiJ MGP_WSBEiJ_G0016986
protein coding gene Chr10:85103149-85204656 (+)



Homology
more
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSyn, RIC8
  • Links
    NCBI Gene ID: 55188
    neXtProt AC: NX_Q9NVN3
    UniProt: Q9NVN3

  • Chr Location
    12q23.3; chr12:106774285-106889316 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035620 Ensembl Gene Model | MGI Sequence Detail 100722 C57BL/6J ±  kb
transcript ENSMUST00000038523 Ensembl | MGI Sequence Detail 3069 Not Applicable  
polypeptide ENSMUSP00000046981 Ensembl | MGI Sequence Detail 560 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 45

    Microarray probesets 3
References
more
  • Summaries
    All 42
    Gene Ontology 1
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:247954 Machado CF, et al., Conditional Deletion of Ric-8b in Olfactory Sensory Neurons Leads to Olfactory Impairment. J Neurosci. 2017 Dec 13;37(50):12202-12213

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory