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Ric8b Gene Detail
Summary
  • Symbol
    Ric8b
  • Name
    RIC8 guanine nucleotide exchange factor B
  • Synonyms
    MGC:58970, Ric-8, Ric-8b
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682307
    NCBI Gene: 237422
Location & Maps
more
  • Sequence Map
    Chr10:84917616-85016446 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      98831 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 41.63 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RIC8B, RIC8 guanine nucleotide exchange factor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSyn, RIC8
  • Links
    NCBI Gene ID: 55188
    neXtProt AC: NX_Q9NVN3

  • Chr Location
    12q23.3; chr12:106774285-106889316 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    25
  • Targeted
    6
  • Genomic Mutations
    1 involving Ric8b
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035620 Ensembl Gene Model | MGI Sequence Detail 98831 C57BL/6J ±  kb
transcript ENSMUST00000038523 Ensembl | MGI Sequence Detail 3068 Not Applicable  
polypeptide ENSMUSP00000046981 Ensembl | MGI Sequence Detail 560 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    265 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 44

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Gene Ontology 2
    Phenotypes 15
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:215736 Jenie RI, et al., Increased ubiquitination and the crosstalk of G protein signaling in cardiac myocytes: involvement of Ric-8B in Gs suppression by Gq signal. Genes Cells. 2013 Dec;18(12):1095-106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory