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Naf1 Gene Detail
Summary
  • Symbol
    Naf1
  • Name
    nuclear assembly factor 1 ribonucleoprotein
  • Synonyms
    LOC234344
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682306
    NCBI Gene: 234344
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:66860217-66890564 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.18 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    250 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682306
protein coding gene Chr8:66859957-66890564 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033655
protein coding gene Chr8:66933092-66965225 (+)
A/J MGP_AJ_G0033637
protein coding gene Chr8:64182692-64212879 (+)
AKR/J MGP_AKRJ_G0033562
protein coding gene Chr8:65946212-65976392 (+)
BALB/cJ MGP_BALBcJ_G0033633
protein coding gene Chr8:64389837-64419177 (+)
C3H/HeJ MGP_C3HHeJ_G0033343
protein coding gene Chr8:66720911-66751123 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034150
protein coding gene Chr8:69445256-69476676 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031097
protein coding gene Chr8:59241391-59270317 (+)
CAST/EiJ MGP_CASTEiJ_G0032668
protein coding gene Chr8:66135684-66171613 (+)
CBA/J MGP_CBAJ_G0033321
protein coding gene Chr8:72032217-72067051 (+)
DBA/2J MGP_DBA2J_G0033475
protein coding gene Chr8:63922374-63953376 (+)
FVB/NJ MGP_FVBNJ_G0033416
protein coding gene Chr8:63126030-63156301 (+)
LP/J MGP_LPJ_G0033563
protein coding gene Chr8:66987265-67020114 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033460
protein coding gene Chr8:74653044-74685129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034168
protein coding gene Chr8:66280216-66311439 (+)
PWK/PhJ MGP_PWKPhJ_G0032377
protein coding gene Chr8:63217375-63247804 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032213
protein coding gene Chr8:65217279-65250937 (+)
WSB/EiJ MGP_WSBEiJ_G0032785
protein coding gene Chr8:66644251-66675030 (+)



Homology
more
  • Human Ortholog
    NAF1, nuclear assembly factor 1 ribonucleoprotein
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NAF1, nuclear assembly factor 1 ribonucleoprotein
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 92345
    neXtProt AC: NX_Q96HR8
    UniProt: Q96HR8

  • Chr Location
    4q32.2; chr4:163109133-163170388 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality between implantation and placentation while heterozygotes show no evident ribosomal pathology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014907 Ensembl Gene Model | MGI Sequence Detail 30348 C57BL/6J ±  kb
transcript ENSMUST00000118009 Ensembl | MGI Sequence Detail 2990 Not Applicable  
polypeptide ENSMUSP00000112640 Ensembl | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010958 H/ACA ribonucleoprotein complex non-core subunit NAF1
  • InterPro Domains
    IPR040309 H/ACA ribonucleoprotein complex non-core subunit Naf1
    IPR007504 H/ACA ribonucleoprotein complex, subunit Gar1/Naf1
    IPR038664 H/ACA RNP complex subunit Gar1/Naf1, Cbf5-binding domain
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 1
Other
Accession IDs
less
MGI:2685020
References
more
  • Summaries
    All 27
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:237554 Stanley SE, et al., Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med. 2016 Aug 10;8(351):351ra107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory