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Rxfp1 Gene Detail
Summary
  • Symbol
    Rxfp1
  • Name
    relaxin/insulin-like family peptide receptor 1
  • Synonyms
    Lgr7, LOC381489
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682211
    NCBI Gene: 381489
Location & Maps
more
  • Sequence Map
    Chr3:79641611-79737880 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96270 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 34.94 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RXFP1, relaxin/insulin like family peptide receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RXFP1, relaxin/insulin like family peptide receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LGR7, RXFPR1
  • Links
    NCBI Gene ID: 59350
    neXtProt AC: NX_Q9HBX9

  • Chr Location
    4q32.1; chr4:158521714-158653372 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Rxfp1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display reduced male fertility, particularly at younger ages and early generations. Impaired nipple development prevents nursing by females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044333 VEGA Gene Model | MGI Sequence Detail 96270 C57BL/6J ±  kb
transcript OTTMUST00000116675 VEGA | MGI Sequence Detail 5382 Not Applicable  
polypeptide OTTMUSP00000065043 VEGA | MGI Sequence Detail 758 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    997 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001666 relaxin receptor 1
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR008112 Relaxin receptor
Molecular
Reagents
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  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGI:2685864
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:86876 Hsu SY, et al., The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol. 2000 Aug;14(8):1257-71
  • Latest
    J:222129 Kaftanovskaya EM, et al., Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice. Biol Reprod. 2015 Apr;92(4):91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory