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Rxfp1 Gene Detail
Summary
  • Symbol
    Rxfp1
  • Name
    relaxin/insulin-like family peptide receptor 1
  • Synonyms
    Lgr7, LOC381489
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682211
    NCBI Gene: 381489
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:79641611-79737880 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96270 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 34.94 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LGR7, RXFPR1
  • Links
    NCBI Gene ID: 59350
    neXtProt AC: NX_Q9HBX9
    UniProt: Q9HBX9

  • Chr Location
    4q32.1; chr4:158521711-158653372 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display reduced male fertility, particularly at younger ages and early generations. Impaired nipple development prevents nursing by females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044333 VEGA Gene Model | MGI Sequence Detail 96270 C57BL/6J ±  kb
    transcript OTTMUST00000116675 VEGA | MGI Sequence Detail 5382 Not Applicable  
    polypeptide OTTMUSP00000065043 VEGA | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      997 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685864
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 8
      Phenotypes 13
    • Earliest
      J:86876 Hsu SY, et al., The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol. 2000 Aug;14(8):1257-71
    • Latest
      J:251792 Marshall SA, et al., Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation. Reprod Biol Endocrinol. 2016 Mar 22;14:11

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory