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Rxfp1 Gene Detail
Summary
  • Symbol
    Rxfp1
  • Name
    relaxin/insulin-like family peptide receptor 1
  • Synonyms
    Lgr7, LOC381489
  • Feature Type
    protein coding gene
  • IDs
    MGI:2682211
    NCBI Gene: 381489
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79641611-79737880 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 34.94 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    997 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2682211
protein coding gene Chr3:79641600-79737951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027316
protein coding gene Chr3:79344776-79448618 (-)
A/J MGP_AJ_G0027278
protein coding gene Chr3:76754828-76851064 (-)
AKR/J MGP_AKRJ_G0027246
protein coding gene Chr3:78518176-78614140 (-)
BALB/cJ MGP_BALBcJ_G0027289
protein coding gene Chr3:76778966-76881362 (-)
C3H/HeJ MGP_C3HHeJ_G0027033
protein coding gene Chr3:78852324-78954655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027735
protein coding gene Chr3:82366207-82473406 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025088
protein coding gene Chr3:72386740-72775303 (-)
CAST/EiJ MGP_CASTEiJ_G0026480
protein coding gene Chr3:78917009-79018975 (-)
CBA/J MGP_CBAJ_G0027008
protein coding gene Chr3:85098360-85207631 (-)
DBA/2J MGP_DBA2J_G0027144
protein coding gene Chr3:76309946-76417822 (-)
FVB/NJ MGP_FVBNJ_G0027112
protein coding gene Chr3:74653293-74749809 (-)
LP/J MGP_LPJ_G0027252
protein coding gene Chr3:80312897-80412145 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027131
protein coding gene Chr3:91351056-91467467 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027793
protein coding gene Chr3:78356676-78460292 (-)
PWK/PhJ MGP_PWKPhJ_G0026214
protein coding gene Chr3:76064608-76165117 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026030
protein coding gene Chr3:77504565-77612855 (-)
WSB/EiJ MGP_WSBEiJ_G0026558
protein coding gene Chr3:78687196-78793147 (-)



Homology
more
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RXFP1, relaxin family peptide receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LGR7, RXFPR1
  • Links
    NCBI Gene ID: 59350
    neXtProt AC: NX_Q9HBX9
    UniProt: Q9HBX9

  • Chr Location
    4q32.1; chr4:158521711-158653372 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display reduced male fertility, particularly at younger ages and early generations. Impaired nipple development prevents nursing by females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034009 Ensembl Gene Model | MGI Sequence Detail 96270 C57BL/6J ±  kb
    transcript ENSMUST00000078527 Ensembl | MGI Sequence Detail 5382 Not Applicable  
    polypeptide ENSMUSP00000077611 Ensembl | MGI Sequence Detail 758 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685864
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:86876 Hsu SY, et al., The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Mol Endocrinol. 2000 Aug;14(8):1257-71
    • Latest
      J:251792 Marshall SA, et al., Relaxin deficiency results in increased expression of angiogenesis- and remodelling-related genes in the uterus of early pregnant mice but does not affect endometrial angiogenesis prior to implantation. Reprod Biol Endocrinol. 2016 Mar 22;14:11

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory