Ift172
Gene Detail

Symbol Name ID

Ift172 intraflagellar transport 172 MGI:2682064

Synonyms

4930553F24Rik, avc1, wim

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.27 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:31253280-31291114 bp, - strand From Ensembl annotation of GRCm38   37835 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:15202  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ift172

Human homologs

Human Homolog		IFT172, intraflagellar transport 172 homolog (Chlamydomonas)
NCBI Gene ID		26160
neXtProt AC		NX_Q9UG01
Human Synonyms		osm-1, SLB, wim
Human Chr (Location)		2p23.3; chr2:27667240-27712571 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(5) Gene trapped(2) Chemically induced(2)
 

Mice homozygous for disruptions in this gene display embryonic lethality during organogenesis, neural tube defects, and developmental patterning abnormalities. Mice homozygous for a conditional allele activated in the early limb bud exhibit polydactyly and short limbs.

 
Human Diseases Modeled Using Mouse Ift172 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cilium assembly, determination of left/right symmetry, ...
Component	cell projection, cilium, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (14)    Tissues (2)    Images (10)
Theiler Stages: 18, 23

Assay Type	Results
RNA in situ	10
Western blot	4

cDNA source data(77)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(77) cDNA(77)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000038564 (Evidence)
Entrez Gene	67661 (Evidence)
UniGene	293023
DFCI	TC1576418, TC1587450
DoTS	DT.110687661, DT.531784, DT.94182892, DT.97333550
Consensus CDS Project	CCDS39054.1
International Mouse Knockout Project Status	Ift172

Sequences

Length	Strain/Species
genomic	ENSMUSG00000038564	Ensembl Gene Model | MGI Sequence Detail	37835	C57BL/6J
transcript	ENSMUST00000041565	Ensembl | MGI Sequence Detail	5407	Not Applicable
polypeptide	ENSMUSP00000049335	Ensembl | MGI Sequence Detail	1749	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(118 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000008933	intraflagellar transport protein 172

References

(Earliest) J:65500 Pazour GJ, et al., Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol. 2000 Oct 30;151(3):709-18
(Latest) J:186861 Sun M, et al., Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse. G3 (Bethesda). 2012 Jan;2(1):143-50
All references(46)

Other accession IDs

MGI:1914911, MGI:4821836