About   Help   FAQ
Cep135 Gene Detail
Summary
  • Symbol
    Cep135
  • Name
    centrosomal protein 135
  • Synonyms
    Cep4, LOC381644, MGC:86039
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681869
    NCBI Gene: 381644
  • Gene Overview
    MyGene.info: CEP135
Location & Maps
more
  • Sequence Map
    Chr5:76588698-76646466 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57769 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CEP135, centrosomal protein 135
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CEP135, centrosomal protein 135
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CEP4, KIAA0635, MCPH8
  • Links
    NCBI Gene ID: 9662
    neXtProt AC: NX_Q66GS9

  • Chr Location
    4q12; chr4:55948808-56033363 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CEP135 associations

Human Disease Mouse Models
       Microcephaly 8, Primary, Autosomal Recessive; MCPH8   OMIM: 614673
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    3 involving Cep135
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026443 VEGA Gene Model | MGI Sequence Detail 57769 C57BL/6J ±  kb
transcript OTTMUST00000065403 VEGA | MGI Sequence Detail 5537 Not Applicable  
polypeptide OTTMUSP00000032596 VEGA | MGI Sequence Detail 1140 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    343 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005341 centrosomal protein of 135 kDa
  • InterPro Domains
    IPR026732 Centrosomal protein of 135kDa
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685890
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:162627 Kinzel D, et al., Pitchfork regulates primary cilia disassembly and left-right asymmetry. Dev Cell. 2010 Jul 20;19(1):66-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory