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Zfat
Gene Detail
Symbol

Name
ID
Zfat
zinc finger and AT hook domain containing
MGI:2681865
Synonyms
LOC380993, MGC:56951, Zfat1, Zfp406
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:68083766-68258856 bp, - strand
From VEGA annotation of GRCm38

  175091 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ZFAT
Gene Tree: Zfat

Human
homologs
ZFAT, zinc finger and AT hook domain containing
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57623
neXtProt AC: NX_Q9P243

Human Synonyms: AITD3, ZFAT1, ZNF406

Human Chr (Location): 8q24.22; chr8:134477788-134713049 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ZFAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Radiation induced(1) Targeted(4)
Genomic Mutations involving Zfat (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac.
 
Phenotype Images(2)
Interactions
Zfat interacts with 94 markers (Mir22, Mir29b-1, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process hematopoietic progenitor cell differentiation, hemopoiesis, ...
Component cytoplasm, nucleoplasm, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (8)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ZFAT ; Xenbase zfat    NEW 
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000033790 (Evidence)
Ensembl Gene Model ENSMUSG00000022335 (Evidence)
Entrez Gene 380993 (Evidence)
UniGene 309526
DFCI TC1584590
DoTS DT.91316959, DT.55143971
NIA Mouse Gene Index U036249
PDB 2ELX, 2ELW, 2RV5, 2RV4
Consensus CDS Project CCDS49623.1, CCDS49624.1
International Mouse Phenotyping Consortium Status Zfat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033790 VEGA Gene Model | MGI Sequence Detail 175091 C57BL/6J ±  kb
transcript OTTMUST00000085129 VEGA | MGI Sequence Detail 3866 Not Applicable 
polypeptide OTTMUSP00000045956 VEGA | MGI Sequence Detail 1237 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(17) UniProt(3)
Polymorphisms
SNPs within 2kb(1382 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017626 zinc finger protein ZFAT
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:209038 Ogawa M, et al., Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection. PLoS One. 2013;8(10):e76254
All references(36)
Other
accession IDs
MGI:2685768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory