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Zfat Gene Detail
Summary
  • Symbol
    Zfat
  • Name
    zinc finger and AT hook domain containing
  • Synonyms
    LOC380993, MGC:56951, Zfat1, Zfp406
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681865
    NCBI Gene: 380993
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:68083764-68258856 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681865
protein coding gene Chr15:68083714-68258922 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021912
protein coding gene Chr15:67637077-67819951 (-)
A/J MGP_AJ_G0021871
protein coding gene Chr15:65085773-65263853 (-)
AKR/J MGP_AKRJ_G0021853
protein coding gene Chr15:66872344-67056034 (-)
BALB/cJ MGP_BALBcJ_G0021878
protein coding gene Chr15:65239918-65417204 (-)
C3H/HeJ MGP_C3HHeJ_G0021651
protein coding gene Chr15:66985801-67165124 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022317
protein coding gene Chr15:70219817-70399871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019854
protein coding gene Chr15:61812852-61991049 (-)
CAST/EiJ MGP_CASTEiJ_G0021170
protein coding gene Chr15:67639477-67866514 (-)
CBA/J MGP_CBAJ_G0021617
protein coding gene Chr15:72539490-72723507 (-)
DBA/2J MGP_DBA2J_G0021742
protein coding gene Chr15:64849717-65028917 (-)
FVB/NJ MGP_FVBNJ_G0021724
protein coding gene Chr15:63872390-64048815 (-)
LP/J MGP_LPJ_G0021814
protein coding gene Chr15:67550575-67740964 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021747
protein coding gene Chr15:77681814-77863259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022339
protein coding gene Chr15:67267576-67444277 (-)
PWK/PhJ MGP_PWKPhJ_G0020911
protein coding gene Chr15:64914562-65113756 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020752
protein coding gene Chr15:67050512-67267690 (-)
WSB/EiJ MGP_WSBEiJ_G0021222
protein coding gene Chr15:67227353-67407329 (-)



Homology
more
  • Human Ortholog
    ZFAT, zinc finger and AT-hook domain containing
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZFAT, zinc finger and AT-hook domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AITD3, ZFAT1, ZNF406
  • Links
    NCBI Gene ID: 57623
    neXtProt AC: NX_Q9P243
    UniProt: Q9P243

  • Chr Location
    8q24.22; chr8:134477788-134713049 (-)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022335 Ensembl Gene Model | MGI Sequence Detail 175093 C57BL/6J ±  kb
    transcript ENSMUST00000160248 Ensembl | MGI Sequence Detail 3866 Not Applicable  
    polypeptide ENSMUSP00000125257 Ensembl | MGI Sequence Detail 1237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2685768
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 4
      Phenotypes 35
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:270991 Tsunoda T, et al., Zfat expression in ZsGreen reporter gene knockin mice: Implications for a novel function of Zfat in definitive erythropoiesis. Int J Mol Med. 2018 Nov;42(5):2595-2603

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory