Zfat
Gene Detail

Symbol Name ID

Zfat zinc finger and AT hook domain containing MGI:2681865

Synonyms

LOC380993, MGC:56951, Zfat1, Zfp406

Feature Type

protein coding gene

Genetic Map

Chromosome 15

29.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:68083766-68258856 bp, - strand From VEGA annotation of GRCm38   175091 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:16829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zfat

Human homologs

Human Homolog		ZFAT, zinc finger and AT hook domain containing
NCBI Gene ID		57623
neXtProt AC		NX_Q9P243
Human Synonyms		AITD3, ZFAT1, ZNF406
Human Chr (Location)		8q24.22; chr8:135490031-135725292 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ZFAT

Alleles and phenotypes

All alleles(22) : Targeted(4) Gene trapped(18)
 

Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	hematopoietic progenitor cell differentiation, hemopoiesis, ...
Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (8)    Images (16)
Theiler Stages: 23

Assay Type	Results
RNA in situ	39

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(19)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000033790 (Evidence)
Ensembl Gene Model	ENSMUSG00000022335 (Evidence)
Entrez Gene	380993 (Evidence)
UniGene	309526
DFCI	TC1584590
DoTS	DT.55143971, DT.91316959
NIA Mouse Gene Index	U036249
PDB	2ELW, 2ELX
Consensus CDS Project	CCDS49623.1, CCDS49624.1
International Mouse Knockout Project Status	Zfat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033790	VEGA Gene Model | MGI Sequence Detail	175091	C57BL/6J
transcript	OTTMUST00000085129	VEGA | MGI Sequence Detail	3866	Not Applicable
polypeptide	OTTMUSP00000045956	VEGA | MGI Sequence Detail	1237	Not Applicable

All sequences(39) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(1013 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017626	zinc finger protein ZFAT

References

(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:187164 Doi K, et al., ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response. Biochem Biophys Res Commun. 2012 Aug 17;425(1):107-12
All references(36)

Other accession IDs

MGI:2685768