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Zfat
Gene Detail
Symbol

Name
ID
Zfat
zinc finger and AT hook domain containing
MGI:2681865
Synonyms
LOC380993, MGC:56951, Zfat1, Zfp406
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:68083766-68258856 bp, - strand
From VEGA annotation of GRCm38

  175091 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:16829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfat

Human
homologs
Human Homolog ZFAT, zinc finger and AT hook domain containing
NCBI Gene ID 57623
neXtProt AC  NX_Q9P243
Human Synonyms  AITD3, ZFAT1, ZNF406
Human Chr (Location)  8q24.22; chr8:134477788-134713049 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZFAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Radiation induced(1) Targeted(4)
Genomic Mutations involving Zfat (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac.
 
Interactions
Zfat interacts with 95 markers (Mir22, Mir29b-1, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process hematopoietic progenitor cell differentiation, hemopoiesis, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (39)    Tissues (8)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000033790 (Evidence)
Ensembl Gene ModelENSMUSG00000022335 (Evidence)
Entrez Gene380993 (Evidence)
UniGene309526
DFCITC1584590
DoTSDT.55143971, DT.91316959
NIA Mouse Gene IndexU036249
PDB2ELW, 2ELX
Consensus CDS ProjectCCDS49623.1, CCDS49624.1
International Mouse Knockout Project StatusZfat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033790 VEGA Gene Model | MGI Sequence Detail 175091 C57BL/6J ±  kb
transcript OTTMUST00000085129 VEGA | MGI Sequence Detail 3866 Not Applicable 
polypeptide OTTMUSP00000045956 VEGA | MGI Sequence Detail 1237 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(15) UniProt(3)
Polymorphisms
SNPs within 2kb(1382 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017626 zinc finger protein ZFAT
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:209038 Ogawa M, et al., Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection. PLoS One. 2013;8(10):e76254
All references(37)
Other
accession IDs
MGI:2685768

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory