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Zfat Gene Detail
Summary
  • Symbol
    Zfat
  • Name
    zinc finger and AT hook domain containing
  • Synonyms
    LOC380993, MGC:56951, Zfat1, Zfp406
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681865
    NCBI Gene: 380993
Location & Maps
more
  • Sequence Map
    Chr15:68083766-68258856 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      175091 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.44 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ZFAT, zinc finger and AT-hook domain containing
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZFAT, zinc finger and AT-hook domain containing
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AITD3, ZFAT1, ZNF406
  • Links
    NCBI Gene ID: 57623
    neXtProt AC: NX_Q9P243

  • Chr Location
    8q24.22; chr8:134477788-134713049 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ZFAT associations

Human Disease Mouse Models
       Autoimmune Thyroid Disease, Susceptibility to, 3; AITD3   OMIM: 608175
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    3
  • Gene trapped
    18
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    5 involving Zfat
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with failure to initiation of embryo turning, abnormal embryonic hematopoiesis, abnormal spongiotrophoblast layer morphology, abnormal visceral yolk sac blood island morphology and pale yolk sac.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033790 VEGA Gene Model | MGI Sequence Detail 175091 C57BL/6J ±  kb
transcript OTTMUST00000085129 VEGA | MGI Sequence Detail 3866 Not Applicable  
polypeptide OTTMUSP00000045956 VEGA | MGI Sequence Detail 1237 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1377 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 5
Other
Accession IDs
less
MGI:2685768
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 4
    Phenotypes 31
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:209038 Ogawa M, et al., Zfat-deficiency results in a loss of CD3zeta phosphorylation with dysregulation of ERK and Egr activities leading to impaired positive selection. PLoS One. 2013;8(10):e76254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory