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Igsf21 Gene Detail
Summary
  • Symbol
    Igsf21
  • Name
    immunoglobulin superfamily, member 21
  • Synonyms
    LOC230868, MGC:67646
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681842
    NCBI Gene: 230868
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139754157-139974095 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 71.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681842
 protein coding gene Chr4:139754157-139974294 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029025
 protein coding gene Chr4:142917782-143157345 (-)
A/J MGP_AJ_G0028984
 protein coding gene Chr4:136756381-136979317 (-)
AKR/J MGP_AKRJ_G0028936
 protein coding gene Chr4:140690821-140928338 (-)
BALB/cJ MGP_BALBcJ_G0029008
 protein coding gene Chr4:137440244-137671617 (-)
C3H/HeJ MGP_C3HHeJ_G0028722
 protein coding gene Chr4:141080635-141318003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029449
 protein coding gene Chr4:147962659-148205557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026720
 protein coding gene Chr4:129706015-129925520 (-)
CAST/EiJ MGP_CASTEiJ_G0028154
 protein coding gene Chr4:139292983-139536859 (-)
CBA/J MGP_CBAJ_G0028686
 protein coding gene Chr4:152176561-152405006 (-)
DBA/2J MGP_DBA2J_G0028836
 protein coding gene Chr4:137156145-137384341 (-)
FVB/NJ MGP_FVBNJ_G0028803
 protein coding gene Chr4:136209182-136446171 (-)
LP/J MGP_LPJ_G0028935
 protein coding gene Chr4:142975766-143208581 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028829
 protein coding gene Chr4:156130781-156363811 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029487
 protein coding gene Chr4:141218187-141447647 (-)
PWK/PhJ MGP_PWKPhJ_G0027875
 protein coding gene Chr4:134022944-134248416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027700
 protein coding gene Chr4:137014297-137260957 (-)
WSB/EiJ MGP_WSBEiJ_G0028232
 protein coding gene Chr4:141493677-141728229 (-)



Homology
more
  • Human Ortholog
    IGSF21, immunoglobin superfamily member 21
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGSF21, immunoglobin superfamily member 21
  • Links
    NCBI Gene ID: 84966
    neXtProt AC: NX_Q96ID5
    UniProt: Q96ID5

  • Chr Location
    1p36.13; chr1:18107798-18378483 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal differentiation of inhibitory synapses with decreased mIPSC frequency and prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    963
  • Tissues
    62
  • cDNA Data
    6
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040972 Ensembl Gene Model | MGI Sequence Detail 219939 C57BL/6J ±  kb
transcript ENSMUST00000039331 Ensembl | MGI Sequence Detail 1979 Not Applicable  
polypeptide ENSMUSP00000046558 Ensembl | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 7
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2684987
References
more
  • Summaries
    All 35
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:84714 Nishijima I, et al., Two new balancer chromosomes on mouse chromosome 4 to facilitate functional annotation of human chromosome 1p. Genesis. 2003 Jul;36(3):142-8
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory