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Aars2 Gene Detail
Summary
  • Symbol
    Aars2
  • Name
    alanyl-tRNA synthetase 2, mitochondrial
  • Synonyms
    Aarsl, MGC:69820
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681839
    NCBI Gene: 224805
  • Gene Overview
    MyGene.info: AARS2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:45506841-45520842 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 22.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681839
protein coding gene Chr17:45506807-45520843 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023788
protein coding gene Chr17:46519829-46535336 (+)
A/J MGP_AJ_G0023746
protein coding gene Chr17:45408810-45422650 (+)
AKR/J MGP_AKRJ_G0023717
protein coding gene Chr17:45717308-45731531 (+)
BALB/cJ MGP_BALBcJ_G0023750
protein coding gene Chr17:45297436-45311617 (+)
C3H/HeJ MGP_C3HHeJ_G0023514
protein coding gene Chr17:46427913-46442923 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024193
protein coding gene Chr17:48531015-48548462 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021643
protein coding gene Chr17:42205655-42219100 (+)
CAST/EiJ MGP_CASTEiJ_G0022995
protein coding gene Chr17:46528339-46541980 (+)
CBA/J MGP_CBAJ_G0023490
protein coding gene Chr17:50254025-50271701 (+)
DBA/2J MGP_DBA2J_G0023616
protein coding gene Chr17:44198971-44212907 (+)
FVB/NJ MGP_FVBNJ_G0023583
protein coding gene Chr17:43775930-43790146 (+)
LP/J MGP_LPJ_G0023697
protein coding gene Chr17:47167432-47181315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023612
protein coding gene Chr17:49825096-49840406 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024238
protein coding gene Chr17:46074871-46092877 (+)
PWK/PhJ MGP_PWKPhJ_G0022740
protein coding gene Chr17:43506721-43520288 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022555
protein coding gene Chr17:42947037-42960578 (+)
WSB/EiJ MGP_WSBEiJ_G0023060
protein coding gene Chr17:46602695-46616668 (+)



Homology
more
  • Human Ortholog
    AARS2, alanyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AARS2, alanyl-tRNA synthetase 2, mitochondrial
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AARSL, COXPD8, LKENP, MTALARS, MT-ALARS
  • Links
    NCBI Gene ID: 57505
    neXtProt AC: NX_Q5JTZ9
    UniProt: Q5JTZ9

  • Chr Location
    6p21.1; chr6:44297850-44313358 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AARS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023938 Ensembl Gene Model | MGI Sequence Detail 14002 C57BL/6J ±  kb
    transcript ENSMUST00000024733 Ensembl | MGI Sequence Detail 3349 Not Applicable  
    polypeptide ENSMUSP00000024733 Ensembl | MGI Sequence Detail 980 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000032745 alanine--tRNA ligase, mitochondrial
    • EC
    • InterPro Domains
      IPR002318 Alanine-tRNA ligase, class IIc
      IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
      IPR023033 Alanine-tRNA ligase, eukaryota/bacteria
      IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
      IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
      IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
      IPR012947 Threonyl/alanyl tRNA synthetase, SAD
      IPR009000 Translation protein, beta-barrel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2684935
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory