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Aars2
Gene Detail
Symbol

Name
ID
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
MGI:2681839
Synonyms
Aarsl, MGC:69820
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:45506841-45520842 bp, + strand
From Ensembl annotation of GRCm38

  14002 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alanyl-tRNA ligase
Gene Tree: Aars2

Human
homologs
Human Homolog AARS2, alanyl-tRNA synthetase 2, mitochondrial
NCBI Gene ID 57505
neXtProt AC  NX_Q5JTZ9
Human Synonyms  AARSL, COXPD8, LKENP, MTALARS, MT-ALARS
Human Chr (Location)  6p21.1; chr6:44298726-44313357 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human AARS2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Aars2 interacts with 75 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process alanyl-tRNA aminoacylation, mitochondrial alanyl-tRNA aminoacylation, ...
Component cytoplasm, mitochondrion
Function alanine-tRNA ligase activity, aminoacyl-tRNA ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(34)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(35) cDNA(34) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000023938 (Evidence)
Entrez Gene224805 (Evidence)
UniGene329063
DFCITC1622866, TC1578362, TC1617798
DoTSDT.101347836, DT.101237969
NIA Mouse Gene IndexU018023
EC6.1.1.7
Consensus CDS ProjectCCDS28809.1
International Mouse Knockout Project StatusAars2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023938 Ensembl Gene Model | MGI Sequence Detail 14002 C57BL/6J ±  kb
transcript ENSMUST00000024733 Ensembl | MGI Sequence Detail 3348 Not Applicable 
polypeptide ENSMUSP00000024733 Ensembl | MGI Sequence Detail 980 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002318 Alanine-tRNA ligase, class IIc
InterPro IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain
InterPro IPR023033 Alanine-tRNA ligase, eukaryota/bacteria
InterPro IPR018165 Alanyl-tRNA synthetase, class IIc, core domain
InterPro IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal
InterPro IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain
InterPro IPR012947 Threonyl/alanyl tRNA synthetase, SAD
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000032745 alanine--tRNA ligase, mitochondrial
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)
Other
accession IDs
MGI:2684935

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory