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Prss34 Gene Detail
Summary
  • Symbol
    Prss34
  • Name
    protease, serine 34
  • Synonyms
    mast cell protease 11, mMcp-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681414
    NCBI Gene: 328780
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25517368-25519139 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681414
protein coding gene Chr17:25517368-25519142 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023349
protein coding gene Chr17:24353727-24355494 (+)
A/J MGP_AJ_G0023308
protein coding gene Chr17:23670541-23672308 (+)
AKR/J MGP_AKRJ_G0023274
protein coding gene Chr17:23764405-23766172 (+)
BALB/cJ MGP_BALBcJ_G0023313
protein coding gene Chr17:23873511-23875278 (+)
C3H/HeJ MGP_C3HHeJ_G0023073
protein coding gene Chr17:24143334-24145101 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023755
protein coding gene Chr17:25416791-25418558 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021231
protein coding gene Chr17:21131079-21132861 (+)
CAST/EiJ MGP_CASTEiJ_G0022575
protein coding gene Chr17:23995270-23997037 (+)
CBA/J MGP_CBAJ_G0023048
protein coding gene Chr17:26280614-26282381 (+)
DBA/2J MGP_DBA2J_G0023178
protein coding gene Chr17:23255068-23256835 (+)
FVB/NJ MGP_FVBNJ_G0023148
protein coding gene Chr17:22985094-22986861 (+)
LP/J MGP_LPJ_G0023255
protein coding gene Chr17:24648920-24650687 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023167
protein coding gene Chr17:25937633-25939400 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023795
protein coding gene Chr17:24050855-24052622 (+)
PWK/PhJ MGP_PWKPhJ_G0022324
protein coding gene Chr17:22018377-22020137 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022142
protein coding gene Chr17:22136753-22138519 (+)
WSB/EiJ MGP_WSBEiJ_G0022638
protein coding gene Chr17:24117259-24119026 (+)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show ameliorated IgE-mediated chronic allergic inflammation in the skin, with reduced microvascular permeability and leukocyte infiltration in the skin lesion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056399 Ensembl Gene Model | MGI Sequence Detail 1772 C57BL/6J ±  kb
    transcript ENSMUST00000037453 Ensembl | MGI Sequence Detail 1220 Not Applicable  
    polypeptide ENSMUSP00000045672 Ensembl | MGI Sequence Detail 318 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 4
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
    • Latest
      J:238924 Iki M, et al., Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016 Dec 22;128(25):2909-2918

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/27/2022
    MGI 6.21
    The Jackson Laboratory