Prss34 MGI Mouse Gene Detail - MGI:2681414

Symbol

Prss34
Name

serine protease 34
Synonyms

mast cell protease 11, mMcp-11

Feature Type

protein coding gene
IDs

MGI:2681414
NCBI Gene: 328780
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:25517368-25519142 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 12.53 cM, cytoband A3.3
Mapping Data

3 experiments

SNPs within 2kb

61 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681414	protein coding gene	Chr17:25517368-25519142 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023349	protein coding gene	Chr17:24353727-24355494 (+)
A/J	MGP_AJ_G0023308	protein coding gene	Chr17:23670541-23672308 (+)
AKR/J	MGP_AKRJ_G0023274	protein coding gene	Chr17:23764405-23766172 (+)
BALB/cJ	MGP_BALBcJ_G0023313	protein coding gene	Chr17:23873511-23875278 (+)
C3H/HeJ	MGP_C3HHeJ_G0023073	protein coding gene	Chr17:24143334-24145101 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023755	protein coding gene	Chr17:25416791-25418558 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021231	protein coding gene	Chr17:21131079-21132861 (+)
CAST/EiJ	MGP_CASTEiJ_G0022575	protein coding gene	Chr17:23995270-23997037 (+)
CBA/J	MGP_CBAJ_G0023048	protein coding gene	Chr17:26280614-26282381 (+)
DBA/2J	MGP_DBA2J_G0023178	protein coding gene	Chr17:23255068-23256835 (+)
FVB/NJ	MGP_FVBNJ_G0023148	protein coding gene	Chr17:22985094-22986861 (+)
LP/J	MGP_LPJ_G0023255	protein coding gene	Chr17:24648920-24650687 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023167	protein coding gene	Chr17:25937633-25939400 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023795	protein coding gene	Chr17:24050855-24052622 (+)
PWK/PhJ	MGP_PWKPhJ_G0022324	protein coding gene	Chr17:22018377-22020137 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022142	protein coding gene	Chr17:22136753-22138519 (+)
WSB/EiJ	MGP_WSBEiJ_G0022638	protein coding gene	Chr17:24117259-24119026 (+)

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MGI Vertebrate Homology

Prss34 stringent orthology
1 mouse;1 rat
Gene Tree

Prss34

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Prss34
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show ameliorated IgE-mediated chronic allergic inflammation in the skin, with reduced microvascular permeability and leukocyte infiltration in the skin lesion.

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All GO Annotations

9
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

21
cDNA Data

4
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS28514.1

Ensembl

ENSMUSG00000056399 (Evidence)
NCBI Gene

328780

			Length	Strain/Species	Flank
genomic	328780	NCBI Gene Model \| MGI Sequence Detail	1775	C57BL/6J	± kb
transcript	NM_178372	RefSeq \| MGI Sequence Detail	1216	BALB/c
polypeptide	NP_848459	RefSeq \| MGI Sequence Detail	318	BALB/c

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UniProt

1 Sequence
InterPro Domains

IPR001314 Peptidase S1A, chymotrypsin family

IPR009003 Peptidase S1, PA clan

IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold

IPR001254 Serine proteases, trypsin domain

IPR018114 Serine proteases, trypsin family, histidine active site

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All nucleic 5

cDNA 4

Primer pair 1

Microarray probesets 1

Summaries

All 20

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 5
Earliest

J:86784 Bergstrom DE, et al., Overlapping deletions spanning the proximal two-thirds of the mouse t complex. Mamm Genome. 2003 Dec;14(12):817-29
Latest

J:238924 Iki M, et al., Basophil tryptase mMCP-11 plays a crucial role in IgE-mediated, delayed-onset allergic inflammation in mice. Blood. 2016 Dec 22;128(25):2909-2918

TSS for Prss34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143150	Chr17:25517363-25517377 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23