Tas2r135 Gene Detail

Summary

• Symbol
  Tas2r135
• Name
  taste receptor, type 2, member 135
• Synonyms
  mt2r38, Tas2r35

• Feature Type
  protein coding gene
• IDs
  MGI:2681302
  NCBI Gene: 387512
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr6:42382463-42383428 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, 20.71 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  116 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2681302	protein coding gene	Chr6:42382368-42383460 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030651	protein coding gene	Chr6:40923781-40924873 (+)
A/J	MGP_AJ_G0030624	protein coding gene	Chr6:39135549-39136641 (+)
AKR/J	MGP_AKRJ_G0030549	protein coding gene	Chr6:40398378-40399470 (+)
BALB/cJ	MGP_BALBcJ_G0030634	protein coding gene	Chr6:39392460-39393552 (+)
C3H/HeJ	MGP_C3HHeJ_G0030347	protein coding gene	Chr6:40435775-40436867 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031088	protein coding gene	Chr6:41947219-41948311 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028295	protein coding gene	Chr6:37017299-37018391 (+)
CAST/EiJ	MGP_CASTEiJ_G0029751	protein coding gene	Chr6:40268852-40269944 (+)
CBA/J	MGP_CBAJ_G0030323	protein coding gene	Chr6:43644576-43645668 (+)
DBA/2J	MGP_DBA2J_G0030467	protein coding gene	Chr6:38985514-38986606 (+)
FVB/NJ	MGP_FVBNJ_G0030423	protein coding gene	Chr6:38734356-38735448 (+)
LP/J	MGP_LPJ_G0030555	protein coding gene	Chr6:40885470-40886562 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030457	protein coding gene	Chr6:45918330-45919422 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031118	protein coding gene	Chr6:40374924-40376016 (+)
PWK/PhJ	MGP_PWKPhJ_G0029463	protein coding gene	Chr6:38549470-38550562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029299	protein coding gene	Chr6:39933695-39934787 (+)
WSB/EiJ	MGP_WSBEiJ_G0029827	protein coding gene	Chr6:40363594-40364686 (+)

Homology

• Human Ortholog
  TAS2R60, taste 2 receptor member 60

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TAS2R60, taste 2 receptor member 60
  
• Synonyms
  T2R56, T2R60
• Links
  HGNC:20639

  NCBI Gene ID: 338398

  UniProt: P59551

  
  
• Chr Location
  7q35; chr7:143443453-143444409 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tas2r135 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: TAS2R60
• Gene Tree
  Tas2r135
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  3
• Genomic Mutations
  1 involving Tas2r135
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  15 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  2

Expression

• Assay Results
  706
• cDNA Data
  4

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS20069.1

• Ensembl
  ENSMUSG00000056203 (Evidence)
• NCBI Gene
  387512

Representative Sequences			Length	Strain/Species
genomic	387512	NCBI Gene Model | MGI Sequence Detail	966	C57BL/6J
transcript	NM_199159	RefSeq | MGI Sequence Detail	966	C57BL/6
polypeptide	Q7TQA9	UniProt | EBI | MGI Sequence Detail	312	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016084 taste receptor type 2 member 60/135
  (term hierarchy)
• InterPro Domains
  IPR007960 Taste receptor type 2
• GlyGen
  Q7TQA9 1 site

Molecular
Reagents

• All nucleic 4

  cDNA 4

  
  

  Microarray probesets 1

References

• Summaries
  All 18

  Gene Ontology 2

  Phenotypes 2
• Earliest
  J:83522 Shi P, et al., Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol. 2003 May;20(5):805-14
• Latest
  J:334098 Kobayashi D, et al., Tas2R signaling enhances mouse neutrophil migration via a ROCK-dependent pathway. Front Immunol. 2022;13:973880