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Pigl Gene Detail
Summary
  • Symbol
    Pigl
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class L
  • Synonyms
    LOC327942
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681271
    NCBI Gene: 327942
Location & Maps
more
  • Sequence Map
    Chr11:62458460-62514417 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55958 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 38.34 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIGL, phosphatidylinositol glycan anchor biosynthesis class L
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIGL, phosphatidylinositol glycan anchor biosynthesis class L
    Orthology source: HomoloGene
  • Synonyms
    CHIME
  • Links
    NCBI Gene ID: 9487
    neXtProt AC: NX_Q9Y2B2

  • Chr Location
    17p11.2; chr17:16217195-16349164 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3159
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PIGL
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PIGL associations

Human Disease Mouse Models
       Coloboma, Congenital Heart Disease, Ichthyosiform Dermatosis, Mental Retardation, and Ear Anomalies Syndrome; CHIME   OMIM: 280000
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    377
  • Chemically induced (other)
    1
  • Gene trapped
    371
  • Targeted
    5
  • Genomic Mutations
    1 involving Pigl
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005858 VEGA Gene Model | MGI Sequence Detail 55958 C57BL/6J ±  kb
transcript OTTMUST00000013037 VEGA | MGI Sequence Detail 2174 Not Applicable  
polypeptide OTTMUSP00000006064 VEGA | MGI Sequence Detail 252 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    211 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000012699 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
  • EC
  • InterPro Domains
    IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related
    IPR024078 Putative deacetylase LmbE-like domain
Molecular
Reagents
less
  • All nucleic 3
    Genomic 1
    cDNA 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2685583
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory