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Tas2r105 Gene Detail
Summary
  • Symbol
    Tas2r105
  • Name
    taste receptor, type 2, member 105
  • Synonyms
    mGR05, mt2r5, T2R05, T2r5, T2R9, Tas2r5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681195
    NCBI Gene: 57252
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:131686561-131687463 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.53 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681195
protein coding gene Chr6:131686532-131687495 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031375
protein coding gene Chr6:135645910-135646873 (-)
A/J MGP_AJ_G0031351
protein coding gene Chr6:130372392-130373355 (-)
AKR/J MGP_AKRJ_G0031279
protein coding gene Chr6:134178686-134179649 (-)
BALB/cJ MGP_BALBcJ_G0031358
protein coding gene Chr6:130066436-130067399 (-)
C3H/HeJ MGP_C3HHeJ_G0031081
protein coding gene Chr6:134260181-134261144 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031815
protein coding gene Chr6:139299282-139300245 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028954
protein coding gene Chr6:128651229-128652192 (-)
CAST/EiJ MGP_CASTEiJ_G0030452
protein coding gene Chr6:134168046-134169009 (-)
CBA/J MGP_CBAJ_G0031040
protein coding gene Chr6:144650878-144651841 (-)
DBA/2J MGP_DBA2J_G0031198
protein coding gene Chr6:129298638-129299601 (-)
FVB/NJ MGP_FVBNJ_G0031147
protein coding gene Chr6:128189053-128190016 (-)
LP/J MGP_LPJ_G0031279
protein coding gene Chr6:135981704-135982667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031186
protein coding gene Chr6:148464406-148465369 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031850
protein coding gene Chr6:134034164-134035127 (-)
PWK/PhJ MGP_PWKPhJ_G0030173
protein coding gene Chr6:127635230-127636193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030000
protein coding gene Chr6:132263302-132264265 (-)
WSB/EiJ MGP_WSBEiJ_G0030539
protein coding gene Chr6:134635072-134636035 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation respond normally to a variety of bitter, sweet, umami, salty and sour stimuli but show a striking and selective impairement in their ability to taste cycloheximide (a bitter tastant). In addition, homozygotes are no longer behaviorally averse to cycloheximide.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 57252 NCBI Gene Model | MGI Sequence Detail 903 C57BL/6J ±  kb
transcript NM_020501 RefSeq | MGI Sequence Detail 903 129X1/SvJ  
polypeptide Q9JKT4 UniProt | EBI | MGI Sequence Detail 300 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:61076 Adler E, et al., A novel family of mammalian taste receptors [see comments]. Cell. 2000 Mar 17;100(6):693-702
  • Latest
    J:228693 Gu F, et al., Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts. Biochem Biophys Res Commun. 2015 Aug 7;463(4):934-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory