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Grip2 Gene Detail
Summary
  • Symbol
    Grip2
  • Name
    glutamate receptor interacting protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681173
    NCBI Gene: 243547
  • Gene Overview
    MyGene.info: GRIP2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:91761509-91827250 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.80 cM, cytoband D2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    434 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681173
protein coding gene Chr6:91761508-91843954 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031051
protein coding gene Chr6:93372360-93461337 (-)
A/J MGP_AJ_G0031020
protein coding gene Chr6:89816149-89901005 (-)
AKR/J MGP_AKRJ_G0030951
protein coding gene Chr6:92306503-92389709 (-)
BALB/cJ MGP_BALBcJ_G0031031
protein coding gene Chr6:89760614-89866621 (-)
C3H/HeJ MGP_C3HHeJ_G0030677
protein coding gene Chr6:92061859-92126824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031490
protein coding gene Chr6:95795198-95862914 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028657
protein coding gene Chr6:87799534-87869364 (-)
CAST/EiJ MGP_CASTEiJ_G0030138
protein coding gene Chr6:92431995-92520011 (-)
CBA/J MGP_CBAJ_G0030717
protein coding gene Chr6:99362192-99431459 (-)
DBA/2J MGP_DBA2J_G0030870
protein coding gene Chr6:88999692-89063709 (-)
FVB/NJ MGP_FVBNJ_G0030824
protein coding gene Chr6:88212639-88296696 (-)
LP/J MGP_LPJ_G0030950
protein coding gene Chr6:93335868-93403831 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030858
protein coding gene Chr6:103413136-103499845 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031517
protein coding gene Chr6:92155077-92238341 (-)
PWK/PhJ MGP_PWKPhJ_G0029854
protein coding gene Chr6:87953940-88022976 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029683
protein coding gene Chr6:91065327-91151751 (-)
WSB/EiJ MGP_WSBEiJ_G0030222
protein coding gene Chr6:92632286-92697822 (-)



Homology
more
  • Human Ortholog
    GRIP2, glutamate receptor interacting protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIP2, glutamate receptor interacting protein 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 80852
    neXtProt AC: NX_Q9C0E4
    UniProt: Q9C0E4

  • Chr Location
    3p25.1; chr3:14489111-14602996 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 16327
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GRIP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    9 phenotype references
Homozygous null mice are born in numbers expected by the Mendelian ratio and show no overt phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030098 Ensembl Gene Model | MGI Sequence Detail 65742 C57BL/6J ±  kb
transcript ENSMUST00000162300 Ensembl | MGI Sequence Detail 5206 Not Applicable  
polypeptide ENSMUSP00000124709 Ensembl | MGI Sequence Detail 1042 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:87486 Akeson EC, Chromosomal inversion discovered in C3H/HeJ mice. JAX Notes. 2003;491:15
  • Latest
    J:248702 Han M, et al., Mice lacking GRIP1/2 show increased social interactions and enhanced phosphorylation at GluA2-S880. Behav Brain Res. 2017 Mar 15;321:176-184

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory