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Plekha8 Gene Detail
Summary
  • Symbol
    Plekha8
  • Name
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8
  • Synonyms
    FAPP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681164
    NCBI Gene: 231999
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:54595111-54645823 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 27.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    271 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681164
protein coding gene Chr6:54595111-54645839 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030763
protein coding gene Chr6:53952436-54003049 (+)
A/J MGP_AJ_G0030732
protein coding gene Chr6:51457708-51510350 (+)
AKR/J MGP_AKRJ_G0030659
protein coding gene Chr6:53201015-53254788 (+)
BALB/cJ MGP_BALBcJ_G0030744
protein coding gene Chr6:51809667-51855519 (+)
C3H/HeJ MGP_C3HHeJ_G0030457
protein coding gene Chr6:53226464-53273736 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031199
protein coding gene Chr6:55161698-55218238 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028405
protein coding gene Chr6:49070145-49121476 (+)
CAST/EiJ MGP_CASTEiJ_G0029860
protein coding gene Chr6:53081012-53133791 (+)
CBA/J MGP_CBAJ_G0030431
protein coding gene Chr6:57427275-57486115 (+)
DBA/2J MGP_DBA2J_G0030581
protein coding gene Chr6:51358130-51403882 (+)
FVB/NJ MGP_FVBNJ_G0030533
protein coding gene Chr6:50944424-50996554 (+)
LP/J MGP_LPJ_G0030666
protein coding gene Chr6:53900030-53946628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030567
protein coding gene Chr6:59963872-60017110 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031229
protein coding gene Chr6:53159016-53212450 (+)
PWK/PhJ MGP_PWKPhJ_G0029573
protein coding gene Chr6:51012290-51066887 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029407
protein coding gene Chr6:52531774-52587152 (+)
WSB/EiJ MGP_WSBEiJ_G0029937
protein coding gene Chr6:53193833-53239532 (+)



Homology
more
  • Human Ortholog
    PLEKHA8, pleckstrin homology domain containing A8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLEKHA8, pleckstrin homology domain containing A8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAPP2
  • Links
    NCBI Gene ID: 84725
    neXtProt AC: NX_Q96JA3
    UniProt: Q96JA3

  • Chr Location
    7p14.3; chr7:30028361-30130483 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231999 NCBI Gene Model | MGI Sequence Detail 50713 C57BL/6J ±  kb
transcript NM_001164361 RefSeq | MGI Sequence Detail 6723 C57BL/6  
polypeptide Q80W71 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR014830 Glycolipid transfer protein domain
    IPR036497 Glycolipid transfer protein superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGI:3034664
References
more
  • Summaries
    All 33
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:236757 West DB, et al., Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. PLoS Genet. 2016 Feb;12(2):e1005691

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory