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Siglecf Gene Detail
Summary
  • Symbol
    Siglecf
  • Name
    sialic acid binding Ig-like lectin F
  • Synonyms
    mSiglec-F, Siglec5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681107
    NCBI Gene: 233186
  • Gene Overview
    MyGene.info: SIGLEC5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43351341-43359475 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2681107
protein coding gene Chr7:43351341-43359531 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032118
protein coding gene Chr7:43359026-43367204 (+)
A/J MGP_AJ_G0032103
protein coding gene Chr7:42477370-42485541 (+)
AKR/J MGP_AKRJ_G0032033
protein coding gene Chr7:43845900-43854084 (+)
BALB/cJ MGP_BALBcJ_G0032108
protein coding gene Chr7:42590096-42598286 (+)
C3H/HeJ MGP_C3HHeJ_G0031824
protein coding gene Chr7:44339375-44347569 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032592
protein coding gene Chr7:45547408-45555543 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029615
protein coding gene Chr7:44598299-44606945 (+)
CAST/EiJ MGP_CASTEiJ_G0031154
protein coding gene Chr7:35512124-35522444 (+)
CBA/J MGP_CBAJ_G0031793
protein coding gene Chr7:46972675-46981095 (+)
DBA/2J MGP_DBA2J_G0031942
protein coding gene Chr7:42277677-42285968 (+)
FVB/NJ MGP_FVBNJ_G0031903
protein coding gene Chr7:41996828-42005007 (+)
LP/J MGP_LPJ_G0032021
protein coding gene Chr7:44090276-44098446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031939
protein coding gene Chr7:45942165-45950319 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032612
protein coding gene Chr7:42961561-42969691 (+)
PWK/PhJ MGP_PWKPhJ_G0030875
protein coding gene Chr7:35707594-35716320 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030714
protein coding gene Chr7:31022669-31030792 (+)
WSB/EiJ MGP_WSBEiJ_G0031268
protein coding gene Chr7:43514930-43523118 (+)



Homology
more
  • Human Ortholog
    SIGLEC5, sialic acid binding Ig like lectin 5
  • Vertebrate Orthologs
    5
  • Human Ortholog
    SIGLEC5, sialic acid binding Ig like lectin 5
    Orthology source: HGNC
  • Synonyms
    CD170, CD33L2, OBBP2, OB-BP2, SIGLEC-5
  • Links
    NCBI Gene ID: 8778
    neXtProt AC: NX_O15389
    UniProt: O15389

  • Chr Location
    19q13.41; chr19:51610967-51630474 (-)  GRCh38.p7

  • Human Ortholog
    SIGLEC8, sialic acid binding Ig like lectin 8
    Orthology source: HomoloGene
  • Synonyms
    SAF2, SIGLEC-8, SIGLEC8L
  • Links
    NCBI Gene ID: 27181
    neXtProt AC: NX_Q9NYZ4
    UniProt: Q9NYZ4

  • Chr Location
    19q13.41; chr19:51450997-51458454 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased lung inflammation in response to ovalbumin challenge with increased eosinophils, delayed eosinophil resolution and impaired eosinophil apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 233186 NCBI Gene Model | MGI Sequence Detail 8135 C57BL/6J ±  kb
transcript NM_145581 RefSeq | MGI Sequence Detail 2529 C57BL/6  
polypeptide Q920G3 UniProt | EBI | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:72919 Angata T, et al., Cloning and characterization of a novel mouse Siglec, mSiglec-F: differential evolution of the mouse and human (CD33) Siglec-3-related gene clusters. J Biol Chem. 2001 Nov 30;276(48):45128-36
  • Latest
    J:238953 Gicheva N, et al., Siglec-F is a novel intestinal M cell marker. Biochem Biophys Res Commun. 2016 Oct 07;479(1):1-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory