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Siglecf Gene Detail
Summary
  • Symbol
    Siglecf
  • Name
    sialic acid binding Ig-like lectin F
  • Synonyms
    mSiglec-F, Siglec5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2681107
    NCBI Gene: 233186
Location & Maps
more
  • Sequence Map
    Chr7:43351341-43359531 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8191 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.25 cM, cytoband B3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SIGLEC5, sialic acid binding Ig like lectin 5
  • Vertebrate Orthologs
    5
  • Human Ortholog
    SIGLEC5, sialic acid binding Ig like lectin 5
    Orthology source: HGNC
  • Synonyms
    CD170, CD33L2, OBBP2, OB-BP2, SIGLEC-5
  • Links
    NCBI Gene ID: 8778
    neXtProt AC: NX_O15389

  • Chr Location
    19q13.41; chr19:51610957-51630474 (-)  GRCh38.p2

  • Human Ortholog
    SIGLEC8, sialic acid binding Ig like lectin 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SAF2, SIGLEC-8, SIGLEC8L
  • Links
    NCBI Gene ID: 27181
    neXtProt AC: NX_Q9NYZ4

  • Chr Location
    19q13.41; chr19:51450997-51458454 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    4
  • Targeted
    8
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit increased lung inflammation in response to ovalbumin challenge with increased eosinophils, delayed eosinophil resolution and impaired eosinophil apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031683 VEGA Gene Model | MGI Sequence Detail 8191 C57BL/6J ±  kb
transcript OTTMUST00000078489 VEGA | MGI Sequence Detail 2510 Not Applicable  
polypeptide OTTMUSP00000041734 VEGA | MGI Sequence Detail 569 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    64 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:86117 Aizawa H, et al., Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics. 2003 Nov;82(5):521-30
  • Latest
    J:203546 Patnode ML, et al., Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem. 2013 Sep 13;288(37):26533-45

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory