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Tdrd6 Gene Detail
Summary
  • Symbol
    Tdrd6
  • Name
    tudor domain containing 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679727
    NCBI Gene: 210510
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43615335-43630299 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    137 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679727
 protein coding gene Chr17:43615334-43631351 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023777
 protein coding gene Chr17:44515326-44530235 (-)
A/J MGP_AJ_G0023735
 protein coding gene Chr17:43510777-43525725 (-)
AKR/J MGP_AKRJ_G0023706
 protein coding gene Chr17:43751674-43766924 (-)
BALB/cJ MGP_BALBcJ_G0023739
 protein coding gene Chr17:43402824-43417797 (-)
C3H/HeJ MGP_C3HHeJ_G0023503
 protein coding gene Chr17:44448883-44464832 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024182
 protein coding gene Chr17:46498792-46514993 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021632
 protein coding gene Chr17:40336765-40351694 (-)
CAST/EiJ MGP_CASTEiJ_G0022984
 protein coding gene Chr17:44485042-44500025 (-)
CBA/J MGP_CBAJ_G0023479
 protein coding gene Chr17:48135540-48150455 (-)
DBA/2J MGP_DBA2J_G0023605
 protein coding gene Chr17:42312351-42327584 (-)
FVB/NJ MGP_FVBNJ_G0023572
 protein coding gene Chr17:41876273-41891278 (-)
LP/J MGP_LPJ_G0023686
 protein coding gene Chr17:45179528-45196166 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023601
 protein coding gene Chr17:47780864-47796801 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024227
 protein coding gene Chr17:44102523-44118267 (-)
PWK/PhJ MGP_PWKPhJ_G0022729
 protein coding gene Chr17:41566486-41582041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022544
 protein coding gene Chr17:40969499-40986162 (-)
WSB/EiJ MGP_WSBEiJ_G0023049
 protein coding gene Chr17:44623320-44641132 (-)



Homology
more
  • Human Ortholog
    TDRD6, tudor domain containing 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TDRD6, tudor domain containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2
  • Links
    NCBI Gene ID: 221400
    neXtProt AC: NX_O60522
    UniProt: O60522

  • Chr Location
    6p12.3; chr6:46687875-46704319 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male fertility associated with arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    30
  • Tissues
    14
  • cDNA Data
    8
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040140 Ensembl Gene Model | MGI Sequence Detail 14965 C57BL/6J ±  kb
    transcript ENSMUST00000045717 Ensembl | MGI Sequence Detail 6563 Not Applicable  
    polypeptide ENSMUSP00000035338 Ensembl | MGI Sequence Detail 2135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR035437 SNase-like, OB-fold superfamily
      IPR002999 Tudor domain
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:101737 Pan J, et al., RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39
    • Latest
      J:247924 MacDonald CC, et al., Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction. Biol Reprod. 2017 May 01;96(5):939-947
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2019
    MGI 6.13     		The Jackson Laboratory