Tdrd6 MGI Mouse Gene Detail - MGI:2679727 - tudor domain containing 6

Symbol

Tdrd6
Name

tudor domain containing 6

Feature Type

protein coding gene
IDs

MGI:2679727
NCBI Gene: 210510
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:43926226-43941190 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.75 cM
Mapping Data

1 experiment

SNPs within 2kb

137 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2679727	protein coding gene	Chr17:43926225-43942737 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023777	protein coding gene	Chr17:44515326-44530235 (-)
A/J	MGP_AJ_G0023735	protein coding gene	Chr17:43510777-43525725 (-)
AKR/J	MGP_AKRJ_G0023706	protein coding gene	Chr17:43751674-43766924 (-)
BALB/cJ	MGP_BALBcJ_G0023739	protein coding gene	Chr17:43402824-43417797 (-)
C3H/HeJ	MGP_C3HHeJ_G0023503	protein coding gene	Chr17:44448883-44464832 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024182	protein coding gene	Chr17:46498792-46514993 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021632	protein coding gene	Chr17:40336765-40351694 (-)
CAST/EiJ	MGP_CASTEiJ_G0022984	protein coding gene	Chr17:44485042-44500025 (-)
CBA/J	MGP_CBAJ_G0023479	protein coding gene	Chr17:48135540-48150455 (-)
DBA/2J	MGP_DBA2J_G0023605	protein coding gene	Chr17:42312351-42327584 (-)
FVB/NJ	MGP_FVBNJ_G0023572	protein coding gene	Chr17:41876273-41891278 (-)
LP/J	MGP_LPJ_G0023686	protein coding gene	Chr17:45179528-45196166 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023601	protein coding gene	Chr17:47780864-47796801 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024227	protein coding gene	Chr17:44102523-44118267 (-)
PWK/PhJ	MGP_PWKPhJ_G0022729	protein coding gene	Chr17:41566486-41582041 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022544	protein coding gene	Chr17:40969499-40986162 (-)
WSB/EiJ	MGP_WSBEiJ_G0023049	protein coding gene	Chr17:44623320-44641132 (-)

Human Ortholog

TDRD6, tudor domain containing 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TDRD6, tudor domain containing 6
Synonyms

bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2
Links

HGNC:21339

NCBI Gene ID: 221400

neXtProt AC: NX_O60522

UniProt: O60522
Chr Location

6p12.3; chr6:46687875-46704319 (+) GRCh38.p7

Alliance of Genome Resources

Tdrd6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TDRD6
Gene Tree

Tdrd6

less

Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
5 images
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male fertility associated with arrested spermatogenesis.

less

All GO Annotations

20
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

14
cDNA Data

9
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tdrd6

ZFIN tdrd6

less

Tdrd6 interacts with 102 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

less

All Sequences

53
RefSeq

14
UniProt

6
CCDS

CCDS28797.1, CCDS50115.1, CCDS89099.1

Ensembl

ENSMUSG00000040140 (Evidence)
NCBI Gene

210510

			Length	Strain/Species	Flank
genomic	ENSMUSG00000040140	Ensembl Gene Model \| MGI Sequence Detail	14965	C57BL/6J	± kb
transcript	ENSMUST00000045717	Ensembl \| MGI Sequence Detail	6563	Not Applicable
polypeptide	ENSMUSP00000035338	Ensembl \| MGI Sequence Detail	2135	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000031299 tudor domain-containing protein 6

(term hierarchy)
InterPro Domains

IPR035437 SNase-like, OB-fold superfamily

IPR002999 Tudor domain

less

All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 2

Summaries

All 34

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 7
Earliest

J:101737 Pan J, et al., RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39
Latest

J:306320 Ho UY, et al., WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Commun Biol. 2021 May 31;4(1):645

TSS for Tdrd6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148149	Chr17:43941577-43941588 (-)	-393 bp
Tssr5122	Chr17:43941519-43941542 (-)	-341 bp
Tssr148148	Chr17:43941201-43941204 (-)	-13 bp
Tssr148147	Chr17:43941181-43941195 (-)	2 bp
Tssr148146	Chr17:43941171-43941180 (-)	14 bp
Tssr148145	Chr17:43939496-43939504 (-)	1,690 bp
Tssr148144	Chr17:43939462-43939470 (-)	1,724 bp
Tssr148143	Chr17:43935299-43935309 (-)	5,886 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 11/26/2022 MGI 6.22