Tdrd6 MGI Mouse Gene Detail - MGI:2679727 - tudor domain containing 6

Tdrd6 Gene Detail

Symbol

Tdrd6
Name

tudor domain containing 6

Feature Type

protein coding gene
IDs

MGI:2679727
NCBI Gene: 210510

Sequence Map

Chr17:43615339-43630299 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

14961 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.75 cM
Mapping Data

1 experiment

Human Ortholog

TDRD6, tudor domain containing 6

Vertebrate Orthologs

8

Human Ortholog

TDRD6, tudor domain containing 6
Orthology source: HomoloGene, HGNC
Synonyms

bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2
Links

HGNC:21339

NCBI Gene ID: 221400

neXtProt AC: NX_O60522
Chr Location

6p12.3; chr6:46687875-46704319 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 19364
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish
HCOP

human homology predictions: TDRD6
Gene Tree

Tdrd6

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a null allele exhibit male fertility associated with arrested spermatogenesis.

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All GO Annotations

12
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

30
Tissues

14
cDNA Data

7
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase tdrd6

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Tdrd6 interacts with 102 markers (Mir7-1, Mir9-1, Mir9-2, ...) View All

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All Sequences

36
RefSeq

14
UniProt

5
CCDS

CCDS28797.1, CCDS50115.1
UniGene

329058

			Length	Strain/Species	Flank
genomic	OTTMUSG00000028302	VEGA Gene Model \| MGI Sequence Detail	14961	C57BL/6J	± kb
transcript	OTTMUST00000070135	VEGA \| MGI Sequence Detail	7055	Not Applicable
polypeptide	OTTMUSP00000035711	VEGA \| MGI Sequence Detail	2134	Not Applicable

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SNPs within 2kb

137 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000031299 tudor domain-containing protein 6
InterPro Domains

IPR002999 Tudor domain

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All nucleic 8

cDNA 7

Primer pair 1

Microarray probesets 2

Summaries

All 26

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 3
Earliest

J:101737 Pan J, et al., RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39
Latest

J:221349 Vourekas A, et al., The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing. Genes Dev. 2015 Mar 15;29(6):617-29

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2016 MGI 6.05