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Tdrd6 Gene Detail
Summary
  • Symbol
    Tdrd6
  • Name
    tudor domain containing 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679727
    NCBI Gene: 210510
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr17:43615339-43630299 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14961 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.75 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TDRD6, tudor domain containing 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TDRD6, tudor domain containing 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA446F17.4, CT41.2, NY-CO-45, SPATA36, TDR2
  • Links
    NCBI Gene ID: 221400
    neXtProt AC: NX_O60522
    UniProt: O60522

  • Chr Location
    6p12.3; chr6:46687875-46704319 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    5 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male fertility associated with arrested spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    30
  • Tissues
    14
  • cDNA Data
    7
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028302 VEGA Gene Model | MGI Sequence Detail 14961 C57BL/6J ±  kb
    transcript OTTMUST00000070135 VEGA | MGI Sequence Detail 7055 Not Applicable  
    polypeptide OTTMUSP00000035711 VEGA | MGI Sequence Detail 2134 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      137 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR035437 SNase-like, OB-fold superfamily
      IPR002999 Tudor domain
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 29
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:101737 Pan J, et al., RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Development. 2005 Sep;132(18):4029-39
    • Latest
      J:247924 MacDonald CC, et al., Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction. Biol Reprod. 2017 May 01;96(5):939-947
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory