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Vsig4
Gene Detail
Symbol

Name
ID
Vsig4
V-set and immunoglobulin domain containing 4
MGI:2679720
Synonyms
CRIg, MGC:36211, Z39IG
Feature Type
protein coding gene
Genetic Map
Chromosome X
42.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:96247203-96293438 bp, - strand
From VEGA annotation of GRCm38

  46236 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48515  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: VSIG4
Gene Tree: Vsig4

Human
homologs
VSIG4, V-set and immunoglobulin domain containing 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 11326
neXtProt AC: NX_Q9Y279

Human Synonyms: CRIg, Z39IG

Human Chr (Location): Xq12-q13.3; chrX:66021738-66040125 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a knock-out allele fail to exhibit complement-dependent clearance of Staphylococcus aureus from the circulation and are more susceptible to Listeria monocytogenes infection.
 
Interactions
Vsig4 interacts with 81 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process negative regulation of interleukin-2 production, negative regulation of T cell proliferation
Component extracellular exosome
External Resources: FuncBase
Expression
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vsig4    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018498 (Evidence)
Ensembl Gene Model ENSMUSG00000044206 (Evidence)
Entrez Gene 278180 (Evidence)
UniGene 26781
DFCI TC1588162
DoTS DT.485040
NIA Mouse Gene Index U039553
PDB 2PND
Consensus CDS Project CCDS30288.1
International Mouse Phenotyping Consortium Status Vsig4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018498 VEGA Gene Model | MGI Sequence Detail 46236 C57BL/6J ±  kb
transcript OTTMUST00000044611 VEGA | MGI Sequence Detail 1432 Not Applicable 
polypeptide OTTMUSP00000020052 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000017352 V-set and immunoglobulin domain-containing protein 4
References
(Earliest) J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
(Latest) J:211649 Liao Y, et al., VSIG4 expression on macrophages facilitates lung cancer development. Lab Invest. 2014 Jul;94(7):706-15
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory