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Vsig4 Gene Detail
Summary
  • Symbol
    Vsig4
  • Name
    V-set and immunoglobulin domain containing 4
  • Synonyms
    CRIg, MGC:36211, Z39IG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679720
    NCBI Gene: 278180
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:96247203-96293438 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 42.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679720
protein coding gene ChrX:96247203-96293438 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035924
protein coding gene ChrX:92629864-92680103 (-)
A/J MGP_AJ_G0035910
protein coding gene ChrX:92788958-92821378 (-)
AKR/J MGP_AKRJ_G0035826
protein coding gene ChrX:95285165-95321731 (-)
BALB/cJ MGP_BALBcJ_G0035893
protein coding gene ChrX:91540547-91577934 (-)
C3H/HeJ MGP_C3HHeJ_G0035601
protein coding gene ChrX:93116543-93152296 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036422
protein coding gene ChrX:95554295-95597847 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033251
protein coding gene ChrX:90787606-90812385 (-)
CAST/EiJ MGP_CASTEiJ_G0034888
protein coding gene ChrX:77622504-77648195 (-)
CBA/J MGP_CBAJ_G0035577
protein coding gene ChrX:98458805-98493391 (-)
DBA/2J MGP_DBA2J_G0035731
protein coding gene ChrX:91989971-92034308 (-)
FVB/NJ MGP_FVBNJ_G0035669
protein coding gene ChrX:91397546-91441409 (-)
LP/J MGP_LPJ_G0035821
protein coding gene ChrX:93633234-93662111 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035704
protein coding gene ChrX:102717421-102753911 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036449
protein coding gene ChrX:92361219-92398654 (-)
PWK/PhJ MGP_PWKPhJ_G0034587
protein coding gene ChrX:75269677-75320158 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034416
protein coding gene ChrX:78451423-78486855 (-)
WSB/EiJ MGP_WSBEiJ_G0035027
protein coding gene ChrX:91196721-91236924 (-)



Homology
more
  • Human Ortholog
    VSIG4, V-set and immunoglobulin domain containing 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    VSIG4, V-set and immunoglobulin domain containing 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRIg, Z39IG
  • Links
    NCBI Gene ID: 11326
    neXtProt AC: NX_Q9Y279
    UniProt: Q9Y279

  • Chr Location
    Xq12; chrX:66021738-66040125 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to exhibit complement-dependent clearance of Staphylococcus aureus from the circulation and are more susceptible to Listeria monocytogenes infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 278180 NCBI Gene Model | MGI Sequence Detail 46236 C57BL/6J ±  kb
transcript NM_177789 RefSeq | MGI Sequence Detail 1434 C57BL/6  
polypeptide NP_808457 RefSeq | MGI Sequence Detail 280 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
References
more
  • Summaries
    All 32
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:255926 Li J, et al., VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. Nat Commun. 2017 Nov 6;8(1):1322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory