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Cyp26c1
Gene Detail
 Symbol
Name
ID
Cyp26c1
cytochrome P450, family 26, subfamily c, polypeptide 1
MGI:2679699
Synonyms EG546726
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:37685680-37693307 bp, + strand
From NCBI annotation of GRCm38

  7628 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:28089  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Cyp26c1

Human
homologs
Human Homolog CYP26C1, cytochrome P450, family 26, subfamily C, polypeptide 1
NCBI Gene ID 340665
neXtProt AC  NX_Q6V0L0
Human Synonyms  FFDD4
Human Chr (Location)  10q23.33; chr10:93060808-93069547 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CYP26C1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and exhibit normal CNS development with no apparent anatomical defects.
 
Interactions
Cyp26c1 interacts with 10 markers (Mir127, Mir214, Mir335, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process anterior/posterior pattern specification, central nervous system development, ...
Function metal ion binding, monooxygenase activity, ...
Expression
Literature Summary: (15 records)
Data Summary: Results (81)    Tissues (46)    Images (28)
Theiler Stages: 11, 12, 13, 15, 17, 19, 20, 22, 24, 26, 28
Assay TypeResults
RNA in situ 77
RT-PCR 4
cDNA source data(4)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000062432 (Evidence)
Entrez Gene546726 (Evidence)
UniGene457750
Consensus CDS ProjectCCDS50428.1
International Mouse Knockout Project StatusCyp26c1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 546726 NCBI Gene Model | MGI Sequence Detail 7628 C57BL/6J ±  kb
transcript NM_001105201 RefSeq | MGI Sequence Detail 1557 C57BL/6 
polypeptide NP_001098671 RefSeq | MGI Sequence Detail 518 C57BL/6 

For the selected sequences
All sequences(10) RefSeq(3) UniProt(1)
Polymorphisms SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR017972 Cytochrome P450, conserved site
InterPro IPR002401 Cytochrome P450, E-class, group I
Protein Ontology PR:000006109 cytochrome P450 26C1
References (Earliest) J:85714 Tahayato A, et al., Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development. Gene Expr Patterns. 2003 Aug;3(4):449-54
(Latest) J:203823 Billings SE, et al., The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89
All references(31)
Other
accession IDs
MGI:3643384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory