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Paqr3 Gene Detail
Summary
  • Symbol
    Paqr3
  • Name
    progestin and adipoQ receptor family member III
  • Synonyms
    6330415A20Rik, RKTG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679683
    NCBI Gene: 231474
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:97082329-97111596 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679683
protein coding gene Chr5:97082329-97111748 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029768
protein coding gene Chr5:98359744-98389988 (-)
A/J MGP_AJ_G0029734
protein coding gene Chr5:94733948-94763245 (-)
AKR/J MGP_AKRJ_G0029680
protein coding gene Chr5:97897961-97927637 (-)
BALB/cJ MGP_BALBcJ_G0029744
protein coding gene Chr5:95740912-95770157 (-)
C3H/HeJ MGP_C3HHeJ_G0029467
protein coding gene Chr5:98230138-98260149 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030199
protein coding gene Chr5:102537912-102569356 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027434
protein coding gene Chr5:90107266-90136509 (-)
CAST/EiJ MGP_CASTEiJ_G0028877
protein coding gene Chr5:96831541-96861994 (-)
CBA/J MGP_CBAJ_G0029437
protein coding gene Chr5:106061683-106092758 (-)
DBA/2J MGP_DBA2J_G0029581
protein coding gene Chr5:94942597-94972134 (-)
FVB/NJ MGP_FVBNJ_G0029540
protein coding gene Chr5:93768703-93799514 (-)
LP/J MGP_LPJ_G0029669
protein coding gene Chr5:99013751-99043927 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029569
protein coding gene Chr5:111135883-111167363 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030232
protein coding gene Chr5:97339383-97369598 (-)
PWK/PhJ MGP_PWKPhJ_G0028596
protein coding gene Chr5:93334076-93367417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028431
protein coding gene Chr5:94994073-95028332 (-)
WSB/EiJ MGP_WSBEiJ_G0028956
protein coding gene Chr5:97649999-97680018 (-)



Homology
more
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RKTG
  • Links
    NCBI Gene ID: 152559
    neXtProt AC: NX_Q6TCH7
    UniProt: Q6TCH7

  • Chr Location
    4q21.21; chr4:78887225-78939428 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Paqr3
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000055725 Ensembl Gene Model | MGI Sequence Detail 29268 C57BL/6J ±  kb
transcript ENSMUST00000069453 Ensembl | MGI Sequence Detail 1375 Not Applicable  
polypeptide ENSMUSP00000069324 Ensembl | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 27

    Microarray probesets 2
Other
Accession IDs
less
MGI:1917996
References
more
  • Summaries
    All 40
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264679 Zhao Z, et al., Hepatic PPARalpha function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1. Hepatology. 2018 Jul;68(1):289-303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory