About   Help   FAQ
Paqr3 Gene Detail
Summary
  • Symbol
    Paqr3
  • Name
    progestin and adipoQ receptor family member III
  • Synonyms
    6330415A20Rik, RKTG
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679683
    NCBI Gene: 231474
Location & Maps
more
  • Sequence Map
    Chr5:97082329-97111596 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29268 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 47.29 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PAQR3, progestin and adipoQ receptor family member 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RKTG
  • Links
    NCBI Gene ID: 152559
    neXtProt AC: NX_Q6TCH7

  • Chr Location
    4q21.21; chr4:78887223-78939428 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Paqr3
  • Incidental Mutations
    APF , CvDC
Targeted deletion of this gene causes faster chemical carcinogen-induced skin cell proliferation, higher epidermal thickness, increased number and size of skin papillomas, shorter tumor latency and delayed tumor regression. Heterozygotes develop tumors earlier and more frequently than control mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023913 VEGA Gene Model | MGI Sequence Detail 29268 C57BL/6J ±  kb
transcript OTTMUST00000058414 VEGA | MGI Sequence Detail 1375 Not Applicable  
polypeptide OTTMUSP00000028298 VEGA | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    187 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012275 progestin and adipoQ receptor family member 3
  • InterPro Domains
    IPR004254 AdipoR/Haemolysin-III-related
Molecular
Reagents
less
  • All nucleic 26
    cDNA 26

    Microarray probesets 2
Other
Accession IDs
less
MGI:1917996
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230431 Xu DQ, et al., PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity. EMBO J. 2016 Mar 1;35(5):496-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory