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Slitrk5 Gene Detail
Summary
  • Symbol
    Slitrk5
  • Name
    SLIT and NTRK-like family, member 5
  • Synonyms
    2610019D03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679448
    NCBI Gene: 75409
  • Gene Overview
    MyGene.info: SLITRK5
Location & Maps
more
  • Sequence Map
    Chr14:111675115-111683134 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8020 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 57.86 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLITRK5, SLIT and NTRK like family member 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLITRK5, SLIT and NTRK like family member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA364G4.2, LRRC11
  • Links
    NCBI Gene ID: 26050
    neXtProt AC: NX_O94991

  • Chr Location
    13q31.2; chr13:87671232-87679616 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Slitrk5 mouse models

Human Disease Mouse Models
       Obsessive-Compulsive Disorder; OCD   OMIM: 164230 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Slitrk5
  • Incidental Mutations
Mice homozygous for a null allele have abnormal medium spiny neuron morphology and exhibit behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033214 Ensembl Gene Model | MGI Sequence Detail 8020 C57BL/6J ±  kb
transcript ENSMUST00000042767 Ensembl | MGI Sequence Detail 4806 Not Applicable  
polypeptide ENSMUSP00000041499 Ensembl | MGI Sequence Detail 957 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    92 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015241 SLIT and NTRK-like protein 5
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 10
    cDNA 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1922659
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Diseases 2
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232355 Ahmari SE, Using mice to model Obsessive Compulsive Disorder: From genes to circuits. Neuroscience. 2016 May 3;321:121-37

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory