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Pak6
Gene Detail
Symbol

Name
ID
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
MGI:2679420
Feature Type
protein coding gene
Genetic Map
Chromosome 2
59.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:118663303-118698020 bp, + strand
From VEGA annotation of GRCm38

  34718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23200  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PAK6
Gene Tree: Pak6

Human
homologs
PAK6, p21 protein (Cdc42/Rac)-activated kinase 6
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56924
neXtProt AC: NX_Q9NQU5

Human Synonyms: PAK5

Human Chr (Location): 15q14; chr15:40217428-40277487 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(4) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele do not exhibit any abnormal phenotype.
 
Interactions
Pak6 interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process actin cytoskeleton organization, activation of protein kinase activity, ...
Component cytoplasm, nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (97)    Tissues (36)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
Northern blot 8
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pak6    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000015368 (Evidence)
Ensembl Gene Model ENSMUSG00000074923 (Evidence)
Entrez Gene 214230 (Evidence)
UniGene 241857
DFCI TC1582986, TC1612738, TC1667272
DoTS DT.101194875, DT.103562774, DT.97351478, DT.97399556
NIA Mouse Gene Index U002281
EC 2.7.11.1
Consensus CDS Project CCDS16580.1
International Mouse Phenotyping Consortium Status Pak6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015368 VEGA Gene Model | MGI Sequence Detail 34718 C57BL/6J ±  kb
transcript OTTMUST00000036422 VEGA | MGI Sequence Detail 4411 Not Applicable 
polypeptide OTTMUSP00000016370 VEGA | MGI Sequence Detail 682 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(9) UniProt(2)
Polymorphisms
SNPs within 2kb(314 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000095 CRIB domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
Protein Ontology PR:000012244 serine/threonine-protein kinase PAK 6
References
(Earliest) J:85954 Qu J, et al., PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. 2003 Oct;23(20):7122-33
(Latest) J:200575 Furnari MA, et al., Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice. PLoS One. 2013;8(4):e61321
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory