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Pak6 Gene Detail
Summary
  • Symbol
    Pak6
  • Name
    p21 (RAC1) activated kinase 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679420
    NCBI Gene: 214230
  • Gene Overview
    MyGene.info: PAK6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:118663303-118698020 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 59.41 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679420
protein coding gene Chr2:118663028-118698020 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026318
protein coding gene Chr2:121355934-121395408 (+)
A/J MGP_AJ_G0026279
protein coding gene Chr2:116437417-116473524 (+)
AKR/J MGP_AKRJ_G0026258
protein coding gene Chr2:119701544-119736480 (+)
BALB/cJ MGP_BALBcJ_G0026292
protein coding gene Chr2:116692814-116727936 (+)
C3H/HeJ MGP_C3HHeJ_G0026038
protein coding gene Chr2:120162184-120198006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026739
protein coding gene Chr2:125368524-125403168 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024119
protein coding gene Chr2:111482761-111517362 (+)
CAST/EiJ MGP_CASTEiJ_G0025500
protein coding gene Chr2:120471117-120507195 (+)
CBA/J MGP_CBAJ_G0026014
protein coding gene Chr2:129791117-129825686 (+)
DBA/2J MGP_DBA2J_G0026153
protein coding gene Chr2:115856120-115891291 (+)
FVB/NJ MGP_FVBNJ_G0026115
protein coding gene Chr2:114685423-114720343 (+)
LP/J MGP_LPJ_G0026254
protein coding gene Chr2:121690972-121726618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026134
protein coding gene Chr2:134160868-134196826 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026794
protein coding gene Chr2:119824505-119859121 (+)
PWK/PhJ MGP_PWKPhJ_G0025236
protein coding gene Chr2:115410583-115445776 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025035
protein coding gene Chr2:118990195-119025798 (+)
WSB/EiJ MGP_WSBEiJ_G0025569
protein coding gene Chr2:120639960-120674572 (+)



Homology
more
  • Human Ortholog
    PAK6, p21 (RAC1) activated kinase 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PAK6, p21 (RAC1) activated kinase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PAK5
  • Links
    NCBI Gene ID: 56924
    neXtProt AC: NX_Q9NQU5
    UniProt: Q9NQU5

  • Chr Location
    15q15.1; chr15:40239091-40277487 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23200
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PAK6
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a null allele do not exhibit any abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074923 Ensembl Gene Model | MGI Sequence Detail 34718 C57BL/6J ±  kb
transcript ENSMUST00000099557 Ensembl | MGI Sequence Detail 4411 Not Applicable  
polypeptide ENSMUSP00000097153 Ensembl | MGI Sequence Detail 682 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:228527 Civiero L, et al., Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. J Neurochem. 2015 Dec;135(6):1242-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory