Satb2
Gene Detail

Symbol Name ID

Satb2 special AT-rich sequence binding protein 2 MGI:2679336

Synonyms

mKIAA1034

Feature Type

protein coding gene

Genetic Map

Chromosome 1

28.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:56793986-56978650 bp, - strand From VEGA annotation of GRCm38   184665 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Satb2

Human homologs

Human Homolog		SATB2, SATB homeobox 2
NCBI Gene ID		23314
neXtProt AC		NX_Q9UPW6
Human Chr (Location)		2q33; chr2:200134223-200335989 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SATB2

Alleles and phenotypes

All alleles(7) : Targeted(5) Gene trapped(2)
 

Homozygous inactivation of this gene causes complete perinatal lethality and craniofacial anomalies, such as cleft palate, micrognathia, microcephaly, decreased tongue size, absent incisors and nasal capsule hypoplasia, and leads to short limbs and defects in osteoblast differentiation and function.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cartilage development, cellular response to organic substance, ...
Component	cytoplasm, histone deacetylase complex, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (383)    Tissues (121)    Images (68)
Theiler Stages: 2, 3, 4, 5, 16, 17, 19, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	361
RT-PCR	21

cDNA source data(25)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(25) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023028 (Evidence)
Ensembl Gene Model	ENSMUSG00000038331 (Evidence)
Entrez Gene	212712 (Evidence)
UniGene	145599
NIA Mouse Gene Index	U021346
Consensus CDS Project	CCDS14965.1
International Mouse Knockout Project Status	Satb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023028	VEGA Gene Model | MGI Sequence Detail	184665	C57BL/6J
transcript	OTTMUST00000055482	VEGA | MGI Sequence Detail	5805	Not Applicable
polypeptide	OTTMUSP00000026565	VEGA | MGI Sequence Detail	733	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(739 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003350	Homeodomain protein CUT
InterPro	IPR010982	Lambda repressor-like, DNA-binding domain
Protein Ontology	PR:000014469	DNA-binding protein SATB2

References

(Earliest) J:85953 FitzPatrick DR, et al., Identification of SATB2 as the cleft palate gene on 2q32-q33. Hum Mol Genet. 2003 Oct 1;12(19):2491-501
(Latest) J:193910 Bormuth I, et al., Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions. J Neurosci. 2013 Jan 9;33(2):641-51
All references(95)