About   Help   FAQ
Mthfsd Gene Detail
Summary
  • Symbol
    Mthfsd
  • Name
    methenyltetrahydrofolate synthetase domain containing
  • Synonyms
    MGC:62465
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679252
    NCBI Gene: 234814
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:121097555-121108415 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.31 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    75 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2679252
protein coding gene Chr8:121091628-121108415 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034208
protein coding gene Chr8:124569007-124585771 (-)
A/J MGP_AJ_G0034188
protein coding gene Chr8:119389139-119405903 (-)
AKR/J MGP_AKRJ_G0034115
protein coding gene Chr8:122873219-122889983 (-)
BALB/cJ MGP_BALBcJ_G0034182
protein coding gene Chr8:119606000-119623152 (-)
C3H/HeJ MGP_C3HHeJ_G0033893
protein coding gene Chr8:123603846-123621318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034702
protein coding gene Chr8:128709456-128726220 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031644
protein coding gene Chr8:112256810-112274552 (-)
CAST/EiJ MGP_CASTEiJ_G0033220
protein coding gene Chr8:123617675-123636326 (-)
CBA/J MGP_CBAJ_G0033866
protein coding gene Chr8:133438428-133455245 (-)
DBA/2J MGP_DBA2J_G0034022
protein coding gene Chr8:118598435-118615222 (-)
FVB/NJ MGP_FVBNJ_G0033965
protein coding gene Chr8:117686898-117703824 (-)
LP/J MGP_LPJ_G0034111
protein coding gene Chr8:124695054-124711818 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034012
protein coding gene Chr8:135745375-135762139 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034720
protein coding gene Chr8:123054494-123073271 (-)
PWK/PhJ MGP_PWKPhJ_G0032922
protein coding gene Chr8:118397950-118415069 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032762
protein coding gene Chr8:121767460-121784039 (-)
WSB/EiJ MGP_WSBEiJ_G0033336
protein coding gene Chr8:123804725-123822875 (-)



Homology
more
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 64779
    neXtProt AC: NX_Q2M296
    UniProt: Q2M296

  • Chr Location
    16q24.1; chr16:86530176-86555235 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11245
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MTHFSD
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 234814 NCBI Gene Model | MGI Sequence Detail 10861 C57BL/6J ±  kb
transcript NM_172761 RefSeq | MGI Sequence Detail 2444 C57BL/6  
polypeptide Q3URQ7 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR002698 5-formyltetrahydrofolate cyclo-ligase
    IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain superfamily
    IPR037171 NagB/RpiA transferase-like
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142752
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:191565 Grote P, et al., The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory