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Mthfsd Gene Detail
Summary
  • Symbol
    Mthfsd
  • Name
    methenyltetrahydrofolate synthetase domain containing
  • Synonyms
    MGC:62465
  • Feature Type
    protein coding gene
  • IDs
    MGI:2679252
    NCBI Gene: 234814
Location & Maps
more
  • Sequence Map
    Chr8:121091628-121108392 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16765 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 70.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MTHFSD, methenyltetrahydrofolate synthetase domain containing
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 64779
    neXtProt AC: NX_Q2M296

  • Chr Location
    16q24.1; chr16:86530176-86555235 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    3
  • Targeted
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027534 VEGA Gene Model | MGI Sequence Detail 16765 C57BL/6J ±  kb
transcript OTTMUST00000068163 VEGA | MGI Sequence Detail 1520 Not Applicable  
polypeptide OTTMUSP00000034400 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    86 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030856 methenyltetrahydrofolate synthase domain-containing protein
  • InterPro Domains
    IPR002698 5-formyltetrahydrofolate cyclo-ligase
    IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR000504 RNA recognition motif domain
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 3
Other
Accession IDs
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MGI:2142752
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
  • Latest
    J:191565 Grote P, et al., The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse. Dev Cell. 2013 Jan 28;24(2):206-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory