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Sh3tc1 Gene Detail
Summary
  • Symbol
    Sh3tc1
  • Name
    SH3 domain and tetratricopeptide repeats 1
  • Synonyms
    MGC:67153
  • Feature Type
    protein coding gene
  • IDs
    MGI:2678949
    NCBI Gene: 231147
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35697180-35739987 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 18.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2678949
protein coding gene Chr5:35697180-35739987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029483
protein coding gene Chr5:33997586-34040284 (-)
A/J MGP_AJ_G0029450
protein coding gene Chr5:32884402-32927989 (-)
AKR/J MGP_AKRJ_G0029399
protein coding gene Chr5:34146588-34189393 (-)
BALB/cJ MGP_BALBcJ_G0029460
protein coding gene Chr5:33397804-33440633 (-)
C3H/HeJ MGP_C3HHeJ_G0029182
protein coding gene Chr5:34155188-34199045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029914
protein coding gene Chr5:35905670-35937394 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027151
protein coding gene Chr5:30641179-30685607 (-)
CAST/EiJ MGP_CASTEiJ_G0028591
protein coding gene Chr5:33254929-33297891 (-)
CBA/J MGP_CBAJ_G0029150
protein coding gene Chr5:36750020-36792716 (-)
DBA/2J MGP_DBA2J_G0029298
protein coding gene Chr5:33029341-33072848 (-)
FVB/NJ MGP_FVBNJ_G0029257
protein coding gene Chr5:32495454-32540754 (-)
LP/J MGP_LPJ_G0029383
protein coding gene Chr5:34421234-34464077 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029287
protein coding gene Chr5:37538355-37581870 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029947
protein coding gene Chr5:33641427-33685013 (-)
PWK/PhJ MGP_PWKPhJ_G0028316
protein coding gene Chr5:32195035-32236685 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028147
protein coding gene Chr5:33109574-33171083 (-)
WSB/EiJ MGP_WSBEiJ_G0028672
protein coding gene Chr5:33703040-33746559 (-)



Homology
more
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SH3TC1, SH3 domain and tetratricopeptide repeats 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 54436
    neXtProt AC: NX_Q8TE82
    UniProt: Q8TE82

  • Chr Location
    4p16.1; chr4:8182072-8241103 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    28
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    8 involving Sh3tc1
  • Incidental Mutations
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 231147 NCBI Gene Model | MGI Sequence Detail 42808 C57BL/6J ±  kb
transcript NM_194344 RefSeq | MGI Sequence Detail 4549 C57BL/6  
polypeptide NP_919325 RefSeq | MGI Sequence Detail 1346 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • InterPro Domains
    IPR001452 SH3 domain
    IPR042772 SH3 domain and tetratricopeptide repeat-containing protein SH3TC1/SH3TC2
    IPR036028 SH3-like domain superfamily
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
Molecular
Reagents
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  • All nucleic 36
    cDNA 36

    Microarray probesets 2
References
more
  • Summaries
    All 47
    Developmental Gene Expression 1
    Diseases 1
    Phenotypes 29
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
10/20/2020
MGI 6.16
The Jackson Laboratory