Kyat3 MGI Mouse Gene Detail - MGI:2677849 - kynurenine aminotransferase 3

Symbol

Kyat3
Name

kynurenine aminotransferase 3
Synonyms

Ccbl2, Kat3, KATIII

Feature Type

protein coding gene
IDs

MGI:2677849
NCBI Gene: 229905
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:142406780-142450672 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 66.69 cM
Mapping Data

1 experiment

SNPs within 2kb

1621 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2677849	protein coding gene	Chr3:142406780-142452631 (+)
129S1/SvImJ	ENSMUSG00200002311	protein coding gene	Chr3:139221004-139266832 (+)
A/J	ENSMUSG00195003989	protein coding gene	Chr3:139397425-139443253 (+)
AKR/J	ENSMUSG00220003221	protein coding gene	Chr3:137800230-137846099 (+)
BALB/cJ	ENSMUSG00180011495	protein coding gene	Chr3:139268055-139313883 (+)
C3H/HeJ	ENSMUSG00175019128	protein coding gene	Chr3:138851544-138897373 (+)
C57BL/6NJ	ENSMUSG00215021913	protein coding gene	Chr3:139589699-139635519 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025697	protein coding gene	Chr3:135958909-136003703 (+)
CAST/EiJ	ENSTCUG00005026807	protein coding gene	Chr3:140006501-140053087 (+)
CBA/J	ENSMUSG00210029303	protein coding gene	Chr3:139537155-139584458 (+)
DBA/2J	ENSMUSG00185003250	protein coding gene	Chr3:140126810-140172676 (+)
FVB/NJ	ENSMUSG00205014022	protein coding gene	Chr3:138422176-138468038 (+)
JF1/MsJ	ENSUMUG00000003093	protein coding gene	Chr3:138937602-138984921 (+)
LP/J	ENSMUSG00230003115	protein coding gene	Chr3:142033749-142079570 (+)
NOD/ShiLtJ	ENSMUSG00190004538	protein coding gene	Chr3:140494023-140539894 (+)
NZO/HlLtJ	ENSMUSG00225002057	protein coding gene	Chr3:144544024-144589878 (+)
PWK/PhJ	ENSLUMG00010020806	protein coding gene	Chr3:138824436-138870541 (+)
SPRET/EiJ	ENSMSPG00010013021	protein coding gene	Chr3:140084001-140130798 (+)
WSB/EiJ	ENSIUOG00005018301	protein coding gene	Chr3:139642661-139688450 (+)

Human Ortholog

KYAT3, kynurenine aminotransferase 3

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KYAT3, kynurenine aminotransferase 3
Synonyms

CCBL2, KAT3, KATIII
Links

HGNC:33238

NCBI Gene ID: 56267

UniProt: Q6YP21
Chr Location

1p22.2; chr1:88921044-88992960 (-) GRCh38

MGI Vertebrate Homology

Kyat3 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: KYAT3
Gene Tree

Kyat3

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Kyat3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

691
Tissues

94
cDNA Data

46
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kyat3

ZFIN kyat3.2

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All Sequences

53
RefSeq

8
UniProt

3
CCDS

CCDS17881.1, CCDS80040.1

Ensembl

ENSMUSG00000040213 (Evidence)
NCBI Gene

229905

			Length	Strain/Species	Flank
genomic	229905	NCBI Gene Model \| MGI Sequence Detail	43893	C57BL/6J	± kb
transcript	NM_173763	RefSeq \| MGI Sequence Detail	2279	C57BL/6
polypeptide	Q71RI9	UniProt \| EBI \| MGI Sequence Detail	455	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005098 kynurenine--oxoglutarate transaminase 3

(term hierarchy)
PDB

2ZJG, 3E2F, 3E2Y, 3E2Z, 5VEP, 5VEQ, 5VER
EC

2.6.1.63, 2.6.1.7, 4.4.1.13
InterPro Domains

IPR004839 Aminotransferase, class I/classII, large domain

IPR051326 Kynurenine--oxoglutarate transaminase

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain
GlyGen

Q71RI9 1 site, 1 O-linked glycan (1 site)

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All nucleic 48

cDNA 47

Primer pair 1

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 1

Diseases 1

Gene Ontology 8

Phenotypes 12
Earliest

J:56834 Yu P, et al., Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease. Mamm Genome. 1999 Sep;10(9):845-52
Latest

J:390093 Bowman CE, et al., Off-target depletion of plasma tryptophan by allosteric inhibitors of BCKDK. Mol Metab. 2025 Jul;97:102165

TSS for Kyat3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32246	Chr3:142406787-142406804 (+)	16 bp
Tssr32247	Chr3:142406805-142406826 (+)	36 bp
Tssr32248	Chr3:142406828-142406866 (+)	67 bp
Tssr32250	Chr3:142437288-142437292 (+)	30,510 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24